|Title:||Epidural administration of therapeutic compounds with sustained rate of release|
|Abstract:||A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.|
|Inventor(s):||Gruber; Andres (San Diego, CA), Murdande; Sharad B. (San Diego, CA), Kim; Taehee (San Diego, CA), Kim; Sinil (Solana Beach, CA)|
|Assignee:||SkyePharma Inc. (San Diego, CA)|
|Filing Date:||Sep 16, 1997|
|Claims:||1. A method for epidural administration to a vertebrate of a therapeutic compound comprising encapsulating a therapeutic compound in a drug delivery system having a sustained release rate of the compound from about 2 to about 7 days, and introducing the drug delivery system in a single epidural dose to the vertebrate, wherein the drug delivery system comprises multivesicular liposomes produced from the group consisting of egg phosphatidylcholines, dipalmitoylphosphatidylcholines, distearoylphosphatidylcholines, dioleoylphosphatidylcholines, dipalmitoylphosphatidylglycerols, dioleoyl-phosphatidylglycerols, and suitable combinations thereof. |
2. The method of claim 1 wherein the multivesicular liposomes further comprise at least one steroid.