Generated: April 25, 2017
|Title:||Epidural administration of therapeutic compounds with sustained rate of release|
|Abstract:||A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.|
|Inventor(s):||Gruber; Andres (San Diego, CA), Murdande; Sharad B. (San Diego, CA), Kim; Taehee (San Diego, CA), Kim; Sinil (Solana Beach, CA)|
|Assignee:||SkyePharma Inc. (San Diego, CA)|
|Filing Date:||Sep 16, 1997|
|Claims:||1. A method for epidural administration to a vertebrate of a therapeutic compound comprising encapsulating a therapeutic compound in a drug delivery system having a sustained release rate of the compound from about 2 to about 7 days, and introducing the drug delivery system in a single epidural dose to the vertebrate, wherein the drug delivery system comprises multivesicular liposomes produced from the group consisting of egg phosphatidylcholines, dipalmitoylphosphatidylcholines, distearoylphosphatidylcholines, dioleoylphosphatidylcholines, dipalmitoylphosphatidylglycerols, dioleoyl-phosphatidylglycerols, and suitable combinations thereof. |
2. The method of claim 1 wherein the multivesicular liposomes further comprise at least one steroid.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.