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Details for Patent: 6,428,529

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Details for Patent: 6,428,529

Title: Epidural administration of therapeutic compounds with sustained rate of release
Abstract:A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.
Inventor(s): Gruber; Andres (San Diego, CA), Murdande; Sharad B. (San Diego, CA), Kim; Taehee (San Diego, CA), Kim; Sinil (Solana Beach, CA)
Assignee: SkyePharma Inc. (San Diego, CA)
Filing Date:Sep 16, 1997
Application Number:08/931,867
Claims:1. A method for epidural administration to a vertebrate of a therapeutic compound comprising encapsulating a therapeutic compound in a drug delivery system having a sustained release rate of the compound from about 2 to about 7 days, and introducing the drug delivery system in a single epidural dose to the vertebrate, wherein the drug delivery system comprises multivesicular liposomes produced from the group consisting of egg phosphatidylcholines, dipalmitoylphosphatidylcholines, distearoylphosphatidylcholines, dioleoylphosphatidylcholines, dipalmitoylphosphatidylglycerols, dioleoyl-phosphatidylglycerols, and suitable combinations thereof.

2. The method of claim 1 wherein the multivesicular liposomes further comprise at least one steroid.
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