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|Title:||Dry mix formulation for bisphosphonic acids|
|Abstract:||Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by direct compression/dry mix tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.|
|Inventor(s):||Bechard; Simon R. (Quebec, CA), Kramer; Kenneth A. (Green Lane, PA), Katdare; Ashok V. (Norristown, PA)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
|Filing Date:||Oct 17, 2000|
|Claims:||1. A pharmaceutical tablet comprising 6.55 mg alendronate monosodium trihydrate, 110.45 mg anhydrous lactose, 80.0 mg microcrystalline cellulose, 1.00 mg magnesium stearate, and 2.00 mg croscarmellose sodium.|
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