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Last Updated: March 29, 2024

Details for Patent: 6,395,746


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Title: Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
Abstract:Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new class of antibiotics (e.g. trovafloxacin). The compositions also contain one or more anti-inflammatory agents (e.g. dexamethasone). The compositions are utilized to treat ophthalmic, otic, and nasal conditions by topically applying the compositions to the affected tissues.
Inventor(s): Cagle; Gerald (Fort Worth, TX), Abshire; Robert L. (Fort Worth, TX), Stroman; David W. (Irving, TX), Yanni; John M. (Burleson, TX)
Assignee: Alcon Manufacturing, Ltd. (Fort Worth, TX)
Filing Date:Sep 22, 2000
Application Number:09/646,799
Claims:1. A method of treating or preventing ophthalmic, otic or nasal infections and attendant inflammation, which comprises topically applying a therapeutically effective amount of a topical ophthalmic, otic or nasal pharmaceutical composition to the affected tissues, said composition comprising one or more compounds of the formula: ##STR5##

wherein

R1 is hydrogen, a pharmaceutically acceptable cation, or (C1-C6) alkyl;

Y, when taken independently, is ethyl, t-butyl, vinyl, cyclopropyl, 2-fluoroethyl, p-fluorophenyl, or o,p-difluorophenyl;

W is hydrogen, F, Cl, Br, C1-C4 alkyl, C1-C4 alkoxy, NH.sub.2 or NHCH.sub.3 ;

A is CH, CF, CCl, COCH.sub.3, C--CH.sub.3, C--CN or N; or

A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five or six membered ring which may contain oxygen or a double bond, and which may have attached thereto R8 which is methyl or methylene; and

R2 is ##STR6##

wherein:

R3, R4, R5, R6, R7, R9, R10 and R25 are each independently H, CH.sub.3, CH.sub.2 NH.sub.2, CH.sub.2 NHCH.sub.3 or CH.sub.2 NHC.sub.2 H.sub.5, and R5, R6, R7, and R9 may also independently be NH.sub.2, NHCH.sub.3 or NHC.sub.2 H.sub.5, provided that not more than three of R3, R4, R5, R6, R7, R9, R10 and R25 are other than hydrogen, and if three of these substituents are not hydrogen, at least one of them is methyl; or

a prodrug of a compound of formula (I) having a free amino group, or a pharmaceutically useful hydrate or salt of a compound of formula (I);

an anti-inflammatory effective amount of a steroidal or non-steroidal anti-inflammatory agent; and

a pharmaceutically acceptable vehicle therefor.

2. A method according to claim 1, wherein the ant-inflammatory agent comprises a glucocorticoid.

3. A topical composition according to claim 2, wherein the glucocorticoid is selected from the group consisting of dexamethasone, AL1529, AL2512, rimexolone, prednisolone, fluorometholone, hydrocortisone, mometasone, fluticasone, beclomethasone, flunisolide, triamcinolone and budesonide.

4. A topical composition according to claim 1, wherein the anti-inflammatory agent comprises a non-steroidal agent selected from the group consisting of prostaglandin H synthetase inhibitors, PAF antagonists, and PDE IV inhibitors.

5. A method according to claim 1, wherein the compound of formula (I) comprises trovafloxacin.

6. A method according to any one of claim 2, 3, or 4, or wherein the compound of formula (I) comprises trovafloxacin.

7. A method according to any one of claim 1, 2, 3, 4, or 5, or wherein the composition is topically applied to the eye to treat ophthalmic infections and attendant inflammation.

8. A method according to any one of claim 1, 2, 3, 4, or 5, wherein the composition is topically instilled in the ear to treat otic infections and attendant inflammation.

9. A method of claim 1 or claim 5, wherein the anti-inflammatory agent comprises dexamethasone.

10. A method according to claim 1 or claim 5, wherein the anti-inflammatory agent comprises nepafenac.

11. A method according to claim 1 or claim 5, wherein the anti-inflammatory agent comprises ketoralac.

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