Generated: May 29, 2017
|Title:||Systematic evolution of ligands by exponential enrichment: tissue SELEX|
|Abstract:||This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, endothelia of the blood brain and CSF-blood barriers, glioblastomas, and lymphomas are described.|
|Inventor(s):||Heilig; Joseph S. (Boulder, CO), Gold; Larry (Boulder, CO)|
|Assignee:||Gilead Sciences, Inc. (Foster City, CA)|
|Filing Date:||Sep 14, 1999|
|Claims:||1. A method of delivering a pharmaceutical to the brain comprising: |
conjugating the pharmaceutical to a nucleic acid ligand of a transporter molecule that is specific to or enhanced in a tissue which acts as a barrier to the brain, to form a ligand-pharmaceutical conjugate; and
administering the ligand-pharmaceutical conjugate to an animal in need of the pharmaceutical, whereby a transporter molecule-ligand-pharmaceutical conjugate complex is formed and whereby the pharmaceutical is delivered to the brain.
2. The method of claim 1 wherein said tissue is cerebral endothelium.
3. The method of claim 1 wherein said tissue is choroid plexus epithelium.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.