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Serving leading biopharmaceutical companies globally:

Cerilliant
McKesson
Daiichi Sankyo
Farmers Insurance
Medtronic
US Department of Justice
Fuji
Boehringer Ingelheim
Chinese Patent Office
Merck

Generated: February 22, 2018

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Title: GABA and L-glutamic acid analogs for antiseizure treatment
Abstract:A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
Inventor(s): Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis Martin (Holland, MI), Franklin; Lloyd Charles (Hamilton, MI), Schwindt; Mark Alan (Holland, MI)
Assignee: Northwestern University (Evanston, IL) Warner-Lambert Company (Ann Arbor, MI)
Filing Date:Oct 16, 1996
Application Number:08/732,065
Claims:1. An individual enantiomeric isomer of the formula (S)-2-(2-methylpropyl)-1,4-butanedioic acid, 4-(1,1-dimethylethyl) ester substantially free of any other isomers thereof.
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Serving leading biopharmaceutical companies globally:

Harvard Business School
QuintilesIMS
Medtronic
Novartis
US Army
Cerilliant
Cantor Fitzgerald
Teva
AstraZeneca
Chinese Patent Office

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