Details for Patent: 6,358,527
✉ Email this page to a colleague
Title: | Fast-dissolving galanthamine hydrobromide tablet |
Abstract: | The present invention is concerned with a fast-dissolving tablet for oral administration comprising as an active ingredient a therapeutically effective amount of galanthamine hydrobromide (1:1) and a pharmaceutically acceptable carrier, characterized in that said carrier comprises a spray dried mixture of lactose monohydrate and microcrystalline cellulose (75:25) as a diluent, and a disintegrant; and with a direct compression process of preparing such fast-dissolving tablets. |
Inventor(s): | Gilis; Paul Marie Victor (Beerse, BE), De Conde ; Valentin Florent Victor (Lommel, BE) |
Assignee: | Janssen Pharmaceutica N.V. (Beerse, BE) |
Filing Date: | Jun 01, 2000 |
Application Number: | 09/585,122 |
Claims: | 1. A method of treating a disorder selected from dementia, mania or nicotine dependence in a patient in need thereof comprising administering to the patient a tablet comprising as an active ingredient a therapeutically effective amount of galanthamine hydrobromide (1:1) and a pharmaceutically acceptable carrier, wherein said carrier comprises a spray-dried mixture of lactose monohydrate and microcrystalline cellulose (75:25) as a diluent, and an insoluble or poorly soluble cross-linked polymer disintegrant. 2. The method of claim 1 wherein the disorder is dementia. 3. The method of claim 2 wherein the disorder is Alzheimer's dementia. 4. The method of claim 1 wherein the disorder is mania. 5. The method of claim 1 wherein the disorder is nicotine dependence. 6. A fast-dissolving galanthamine hydrobromide (1:1) tablet made by (i) dry blending the active ingredient, an insoluble or poorly soluble cross-linked polymer disintegrant and an optional glidant with a diluent comprising a spray-dried mixture of lactose monohydrate and microcrystalline cellulose (75:25); (ii) optionally mixing a lubricant with the mixture obtained in step (i); (iii) compressing the mixture obtained in step (i) or in step (ii) in the dry state into a tablet; and (iv) optionally film-coating the tablet obtained in step (iii). |