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Details for Patent: 6,358,504

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Details for Patent: 6,358,504

Title: Compounds and compositions for delivering active agents
Abstract:Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Inventor(s): Leone-Bay; Andrea (Ridgefield, CT), Wang; Eric (Yonkers, NY), Sarubbi; Donald J. (Bronxville, NY), Leipold; Harry (Elmsford, NY), Ho; Koc-Kan (Monmouth Junction, NJ), Gschneidner; David (Stamford, CT)
Assignee: Emisphere Technologies, Inc. (Tarrytown, NY)
Filing Date:Feb 07, 1997
Application Number:08/796,336
Claims:1. A composition comprising:

(A) at least one active agent; and

(B) a compound having the formula ##STR23##

or a salt thereof.

2. The composition of claim 1, wherein said active agent is selected from the group consisting of a biologically active agent, a chemically active agent, or a combination thereof.

3. The composition of claim 2, wherein said active agent comprises a biologically active agent.

4. The composition of claim 3, wherein said biologically active agent comprises at least one peptide, mucopolysaccharide, carbohydrate, or lipid.

5. The composition of claim 4, wherein said biologically active agent comprises at least one peptide.

6. The composition of claim 4, wherein said biologically active agent comprises at least one mucopolysaccharide.

7. The composition of claim 2, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-I, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine, an anti-microbial or any combination thereof.

8. The composition of claim 7, wherein said biologically active agent comprises an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, oxytocin, vasopressin, vancomycin, desferrioxamine, parathyroid hormone, human growth hormone, cromolyn sodium, an anti-microbial or a combination thereof.

9. The composition of claim 8, wherein said biologically active agent is human growth hormone.

10. The composition of claim 8, wherein said biologically active agent is an interferon.

11. The composition of claim 8, wherein said biologically active agent is insulin.

12. The composition of claim 8, wherein said biologically active agent is heparin, low molecular weight heparin, or combinations thereof.

13. The composition of claim 8, wherein said biologically active agent is calcitonin.

14. The composition of claim 8, wherein said biologically active agent is parathyroid hormone.

15. The composition of claim 8, wherein said biologically active agent is cromolyn sodium.

16. The composition of claim 8, wherein said biologically active agent is an anti-microbial.
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