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|Title:||Relating to organic compounds|
|Abstract:||A polylactide in a purified state, which meets the requirements of the color strengths of reference solutions B.sub.2 -B.sub.9 of the brown color test of the European Pharmacopoeia, 2nd Edition (1980) part I, Section V, 6.2 and containing one or more metals in cationic form, the metal ion(s) having a concentration of at most 10 ppm. The polylactide is especially suitable for use as microparticles or implants, and contains preferably a hydrophilic drug, like octreotide or a lipophilic drug like bromocriptine.|
|Inventor(s):||Prikoszovich; Walter (Schonenbuch, CH)|
|Assignee:||Novartis AG (Basel, CH)|
|Filing Date:||Jun 03, 1998|
|Claims:||1. A purified linear polylactide polymer which is a linear polylactide-glycolide having a mean molecular weight Mw of from 46,000 to 60,000, a polydispersity Mw/.sub.Mn of from 1.7 to 3.0, prepared by the process of polymerizing lactide and glycolide in the presence of tin di-(2-ethylhexanoate), followed by treatment with an amount of active charcoal equal to the weight of the polymer and ultrafiltration to yield a colorless or off-white product containing 1 to 1.5 parts per million Sn.sup.++ residue. |
2. The polylactide polymer of claim 1 having a lactidal glycolide molar ratio of 100-25/0-75.
3. The polylactide polymer of claim 1 having a lactide/glycolide molar ratio of 75-25/25-75.
4. The polylactide polymer of claim 1 having a lactide/glycolide molar ratio of 60-40/40-60.
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