|Title:||Relating to organic compounds|
|Abstract:||A polylactide in a purified state, which meets the requirements of the color strengths of reference solutions B.sub.2 -B.sub.9 of the brown color test of the European Pharmacopoeia, 2nd Edition (1980) part I, Section V, 6.2 and containing one or more metals in cationic form, the metal ion(s) having a concentration of at most 10 ppm. The polylactide is especially suitable for use as microparticles or implants, and contains preferably a hydrophilic drug, like octreotide or a lipophilic drug like bromocriptine.|
|Inventor(s):||Prikoszovich; Walter (Schonenbuch, CH)|
|Assignee:||Novartis AG (Basel, CH)|
|Filing Date:||Jun 03, 1998|
|Claims:||1. A purified linear polylactide polymer which is a linear polylactide-glycolide having a mean molecular weight Mw of from 46,000 to 60,000, a polydispersity Mw/.sub.Mn of from 1.7 to 3.0, prepared by the process of polymerizing lactide and glycolide in the presence of tin di-(2-ethylhexanoate), followed by treatment with an amount of active charcoal equal to the weight of the polymer and ultrafiltration to yield a colorless or off-white product containing 1 to 1.5 parts per million Sn.sup.++ residue. |
2. The polylactide polymer of claim 1 having a lactidal glycolide molar ratio of 100-25/0-75.
3. The polylactide polymer of claim 1 having a lactide/glycolide molar ratio of 75-25/25-75.
4. The polylactide polymer of claim 1 having a lactide/glycolide molar ratio of 60-40/40-60.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.