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Details for Patent: 6,346,611

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Details for Patent: 6,346,611

Title: High affinity TGf.beta. nucleic acid ligands and inhibitors
Abstract:Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.2. Included in the invention are specific RNA ligands to TGF.beta.2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.2 with its receptor.
Inventor(s): Pagratis; Nikos (Boulder, CO), Lochrie; Michael (Louisville, CO), Gold; Larry (Boulder, CO)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Filing Date:Jul 29, 1999
Application Number:09/363,939
Claims:1. A purified and isolated non-naturally occurring RNA ligand to transforming growth factor .beta.2 (TGF.beta.2) wherein said ligand is selected from the group consisting of the sequences set forth in Tables 5, 7, 8, 11, 13, 14, 16-19, and FIG. 9 (SEQ ID NOS: 21-121 and 128-193).

2. The purified and isolated non-naturally occurring RNA ligand of claim 1 comprising SEQ ID NO:115 conjugated to polyethylene glycol (PEG), having the following structure: ##STR1##

wherein

X=PEG, and

LIGAND=rGrGrArGrGfUfUrAfUfUrAfCrArGrArGfUfCfUrGfUfUrArGfCfUrGfUrAfCfUfCfC-3 '-3'-dT.

3. The purified and isolated non-naturally occurring RNA ligand of claim 2 wherein said PEG has a molecular weight of about between 10-80 K.

4. The purified and isolated non-naturally occurring RNA ligand of claim 2 wherein said PEG has a molecular weight of about 20-45 K.

5. The purified and isolated non-naturally occurring RNA ligand of claim 2, wherein said ligand is ##STR2##

LIGAND=rGrGrArGrGfUfUrAfUfUrAfCrArGrArGfUfCfUrGfUfUrArGfCfUrGfUrAfCfUfCfC-3 '-3'-dT

(SEQ ID NO:115), wherein rG is 2'OH G, rA is 2'OH A, fU is 2'F U and fC is 2'F C.
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