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Generated: December 11, 2017

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Title: Method for producing a granule
Abstract:The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
Inventor(s): Makino; Tadashi (Osaka, JP), Tabata; Tetsuro (Osaka, JP), Hirai; Shin-Ichiro (Kyoto, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Filing Date:Jun 07, 2000
Application Number:09/588,956
Claims:1. A method for producing a granule which comprises coating nonpareils with a mixture of a benzimidazole compound, a basic inorganic salt stabilizing agent and an additive.

2. A method of claim 1, wherein the basic inorganic salt stabilizing agent has pH of not less than 7 when it is in the form of a 1% aqueous solution or suspension.

3. A method of claim 1, wherein the amount of the basic inorganic salt stabilizing agent relative to parts by weight of the benzimidazole compound is about 0.3 to 20 parts by weight.

4. A method of claim 1, wherein the basic inorganic salt stabilizing agent is a basic inorganic salt of magnesium.

5. A method of claim 1, wherein the basic inorganic salt stabilizing agent is a basic inorganic salt of calcium.

6. A method of claim 1, wherein the benzimidazole compound is a compound of the formula; ##STR8##

wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbarricyl, carbamoylalkyl, hydroxy, alkoxy hydrexyalkyl, trifluoromethyl, acyl carbamoylory, nitro, acyloxy, aryl, aryloxy, alkyithic or alkylsulfinyl:

R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbarnoyl, alkylcarbamoyl, dialkylcarbarnoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl;

R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy;

R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy; and

m is an integer from 0 to 4.

7. A method of claim 1, wherein the benzimidazole compound is 2-[3-methyl-4-(2,2,2-trifluoroethoxy-2-pyridyl)methylsulfinyl]benzimidazol e.
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