Details for Patent: 6,284,266

Title:	Methods and apparatus for improved administration of fentanyl and sufentanil
Abstract:	Methods and apparatus for improving administration of analgesics through the use of heat. The present invention relates to the use of heat in conjunction with specially designed transdermal analgesic delivery systems and conventional commercial transdermal analgesic delivery systems to alter, mainly increase, the analgesic release rate from the transdermal analgesic delivery systems or the depot sites to accommodate certain clinical needs.
Inventor(s):	Zhang; Jie (Salt Lake City, UT), Zhang; Hao (Salt Lake City, UT)
Assignee:	Zars, Inc. (Salt Lake City, UT)
Filing Date:	Sep 29, 1998
Application Number:	09/162,587
Claims:	1. A method of controlling the rate of analgesic delivery to a systemic circulation of a human body comprising: applying a transdermal analgesic delivery system to the skin of said human body for delivery of an analgesic to said systemic circulation of said human body; applying a temperature modification apparatus capable of generating controlled heat proximate said transdermal analgesic delivery system by exposing an oxygen activated exothermic medium within the apparatus to oxygen and varying the amount of oxygen to which the exothermic medium is exposed to vary a rate of reaction of the exothermic medium; and heating said skin of said human body proximate said transdermal analgesic delivery system with said temperature modification apparatus to achieve an increased rate of delivery of analgesic to said systemic circulation of said human body. 2. The method of claim 1, wherein said applying said temperature modification apparatus capable of generating heat proximate said transdermal analgesic delivery system comprises applying said temperature modification apparatus to said transdermal analgesic delivery system. 3. The method of claim 1, wherein said heating said transdermal analgesic delivery system includes heating said skin of said human body proximate said transdermal analgesic delivery system up to a temperature of about 60.degree. C. 4. The method of claim 1, wherein said heating said skin of said human body effectuates an increase in said rate of analgesic delivery to said systemic circulation of said human body through increasing skin permeability by said heating. 5. The method of claim 1, wherein said heating said skin of said human body effectuates an increase in said rate of analgesic delivery to said systemic circulation of said human body through increasing the permeability of blood vessel walls in sub-skin tissues by said heating. 6. The method of claim 1, wherein said heating said skin of said human body effectuates an increase in said rate of analgesic delivery to said systemic circulation of said human body through driving said analgesic in depot sites in tissues under said transdermal analgesic delivery system into the systemic circulation at faster rates by said heating. 7. The method of claim 1, wherein said heating said skin of said human body effectuates an increase in said rate of analgesic delivery to said systemic circulation of said human body through increasing circulation of body fluid in tissues proximate said transdermal analgesic deliver system by said heating. 8. The method of claim 1, wherein said applying said temperature modification apparatus proximate said transdermal administered analgesic comprises applying said temperature modification apparatus proximate said temperature when breakthrough pain occurs. 9. The method of claim 8, further including discontinuing temperature adjustment when said breakthrough pain diminishes. 10. The method of claim 1, further including discontinuing said heating of said skin of said human body with said temperature modification apparatus when a desired clinical effect in said human body is achieved. 11. The method of claim 1, further including removing said temperature modification apparatus when a desired clinical effect in said human body is achieved. 12. The method of claim 1, further including terminating said heating said skin with a heat termination mechanism after a pre-determined duration of time.