Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Pellet-type formulation intended for treating the intestinal tract|
|Abstract:||An orally adminsterable pharmaceutical pellet formulation for the treatment of the intestinal tract is disclosed, which comprises a core and an enteric coating, the core including, as a pharmaceutical active compound, aminosalicyclic acid or a pharmaceutically tolerable salt or a derivative thereof.|
|Inventor(s):||Otterbeck; Norbert (Uberlingen, DE)|
|Assignee:||Dr. Falk Pharma GmbH (DE)|
|Filing Date:||Aug 30, 1999|
|Claims:||1. An orally administrable pharmaceutical pellet formulation having a controlled release profile for the treatment of the intestinal tract, which comprises a core and an enteric coating, the core including, as a pharmaceutically active compound, 5-aminosalicylic acid, or a pharmaceutically tolerable salt thereof, homogeneously dispersed in a non gel-forming polymer matrix which extends through the entire core and which is essentially insoluble in the intestinal tract and permeable to intestinal fluids; |
wherein the matrix is a poly(ethyl acrylate, methyl methacrylate) 2:1 matrix; and
wherein the matrix-forming polymer makes up at least 1% by weight of the total weight of the core; and
wherein the enteric coating comprises poly(methacrylic acid, methyl methacrylates) 1:1 or 1:2; and
wherein the release of said active compound in 0.1 M HCl after 2 hours is <10%; the release of said active compound in artificial gastric juice at pH=6.8 after 0.5 hours is 10-30%, after 2 hours is 40-60% and after 6 hours is at least 80%.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.