Details for Patent: 6,262,071
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Title: | Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria |
Abstract: | This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against certain pathogenic bacteria. |
Inventor(s): | Crabb; Donna M. (Birmingham, AL), Duffy; Lynn B. (Birmingham, AL), Searcy; Karen B. (Birmingham, AL) |
Assignee: | SmithKline Beecham Corporation (Philadelphia, PA) |
Filing Date: | Sep 21, 1999 |
Application Number: | 09/399,855 |
Claims: | 1. A method for modulating metabolism of pathogenic Mycoplasma bacteria comprising the step of contacting pathogenic Mycoplasma bacteria with an antibacterially effective amount of a composition comprising a gemifloxacin compound, or antibacterially effective derivatives thereof. 2. The method of claim 1 wherein said pathogenic Mycoplasma bacteria is a member of the genus Mycoplasma. 3. The method of claim 1 wherein said modulating metabolism is inhibiting growth of said bacteria. 4. The method of claim 1 wherein said modulating metabolism is killing said bacteria. 5. The method of claim 1 wherein said contacting said bacteria comprises the further step of introducing said composition into a mammal. 6. The method of claim 5 wherein said mammal is a human. 7. The method of claim 2 wherein said bacteria is selected from the group consisting of: Mycoplasma hominis and Mycoplasma fermentans. 8. The method of claim 1 wherein said bacteria is a member of the genus Ureaplasma. 9. The method of claim 8 wherein said bacteria is Ureaplasma urealyticum. 10. The method of claim 2 wherein said bacteria is selected from the group consisting of: Mycoplasma pneuoniae, Mycoplasma genitalium, and Mycoplasma penetrans. 11. The method according to claim 1, 2, 7, 8, 9 or 10 wherein the gemifloxacin compound is gemifloxacin or a pharmaceutically acceptable salt thereof. 12. The method according to claim 11 wherein the gemifloxacin compound is gemifloxacin mesylate or a hydrate thereof. 13. The method according to claim 12 wherein the gemifloxacin compound is gemifloxacin mesylate sesquihydrate. |