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Details for Patent: 6,248,788

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Details for Patent: 6,248,788

Title: Therapeutic method with capsaicin and capasicin analogs
Abstract:Application of capsaicin (or a capsaicin analog) in a concentration from about 5% to about 10% by weight has been discovered to be an extremely effective therapy for treating neuropathic pain. In the practice of the present invention, a regional anesthetic, preferably by means of a somatic or neuraxial block, is administered to the affected area to minimize the expected side effects from them subsequent capsaicin application. Using the protocols described, patients with previously resistant neuropathic pain have experienced pain relief for periods of two to seven weeks.
Inventor(s): Robbins; Wendye R. (San Francisco, CA), Staats; Peter S. (Towson, MD), Pappagallo; Marco (Baltimore, MD)
Assignee: The Regents of the University of California (Oakland, CA)
Filing Date:Nov 06, 1996
Application Number:08/746,207
Claims:1. A method for treating neuropathic pain of a human patient, said method comprising:

administering an afferent nerve fiber blocking regional anesthetic to the affected area; and

administering a composition comprising capsaicin or a capsaicin analog, the capsaicin or capsaicin analog being present in a total concentration from about 5% by weight to about 10% by weight, wherein said composition is therapeutically effective in treating neuropathic pain in the affected area, and further wherein no more than two administrations are sufficient to afford significant relief of said neuropathic pain for at least two weeks.

2. The method as in claim 1 wherein said capsaicin or capsaicin analogue is capsaicin and the anesthetic is administered as a somatic block.

3. The method as in claim 1 wherein said capsaicin or capsaicin analog is a capsaicin analog.

4. The method as in claim 1 wherein the composition comprises both capsaicin and one or more capsaicin analogs.

5. The method as in claim 1 wherein the composition is administered topically.

6. The method as in claim 5 wherein the composition also includes an agent having skin absorbing properties.

7. The method as in claim 5 wherein the composition also includes an agent having skin penetrating properties.

8. The method as in claim 5, wherein said capsaicin or capsaicin analog is capsaicin.

9. The method as in claim 8, wherein said capsaicin or capsaicin analog is at a concentration of about 7.5% by weight or greater.

10. The method as in claim 5, wherein said capsaicin or capsaicin analog is a capsaicin analog.

11. The method as in claim 1 wherein the anesthetic is administered as a somatic block.

12. The method as in claim 1 wherein the anesthetic is administered as an epidural.

13. The method as in claim 1 further comprising the step of administering a narcotic analgesic.

14. The method as in claim 1 wherein the total concentration of the capsaicin or capsaicin analog is about 7.5% by weight or greater.

15. The method as in claim 1 wherein the composition comprises capsaicin and the anesthetic is administered as a neuroaxial block.

16. The method as in claim 1 wherein the composition comprises capsaicin and the anesthetic is administered as an epidural.

17. The method as in claim 1 wherein the anesthetic is administered as a neuroaxial block.
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