|Title:|| Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis|
|Abstract:||Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.|
|Inventor(s):|| von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD) |
|Assignee:|| Pro-Neuron, Inc. (Gaithersburg, MD) |
|Filing Date:||Jun 07, 1995|
|Claims:||1. A method for treating cachexia comprising administering to an animal a therapeutically effective amount of uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof. |
2. A method as in claim 1 wherein said acyl derivative of uridine is triacetyluridine.
3. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase.
4. A method for treating cachexia comprising administering to an animal a therapeutically effective amount of an inhibitor of uridine phosphorylase.