Details for Patent: 6,232,298
✉ Email this page to a colleague
Title: | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
Abstract: | Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed. |
Inventor(s): | von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD) |
Assignee: | Pro-Neuron, Inc. (Gaithersburg, MD) |
Filing Date: | Jun 07, 1995 |
Application Number: | 08/479,519 |
Claims: | 1. A method for treating cachexia comprising administering to an animal a therapeutically effective amount of uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof. 2. A method as in claim 1 wherein said acyl derivative of uridine is triacetyluridine. 3. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase. 4. A method for treating cachexia comprising administering to an animal a therapeutically effective amount of an inhibitor of uridine phosphorylase. |