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Generated: August 16, 2017

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Title: Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
Abstract:Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
Inventor(s): von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD)
Assignee: Pro-Neuron, Inc. (Gaithersburg, MD)
Filing Date:Jun 07, 1995
Application Number:08/479,519
Claims:1. A method for treating cachexia comprising administering to an animal a therapeutically effective amount of uridine, cytidine, orotic acid, or an acyl derivative of uridine, cytidine, or orotic acid, or a pharmaceutically acceptable salt thereof.

2. A method as in claim 1 wherein said acyl derivative of uridine is triacetyluridine.

3. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase.

4. A method for treating cachexia comprising administering to an animal a therapeutically effective amount of an inhibitor of uridine phosphorylase.
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