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|Title:||Methods and compositions for inhibition of angiogenesis|
|Abstract:||The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, the invention comprise the compound EM-138 and its use in the inhibition of angiogenesis and treatment of angiogenesis associate diseases, including the inhibition of tumor growth and metastasis.|
|Inventor(s):||Green; Shawn J. (Vienna, VA), Swartz, Jr.; Glenn M. (Jessup, MD), Shah; Jamshed H. (Columbia, MD), Madsen; John (Knoxville, MD), D'Amato; Robert J. (Cambridge, MA)|
|Assignee:||The Children's Medical Center (Cambridge, MA)|
|Filing Date:||Mar 26, 1999|
|Claims:||1. A method of treating an eye condition associated with angiogenesis in a human or animal comprising administering to said human or animal an angiogenesis inhibiting amount of EM-138, ##STR19## |
2. The method of claim 1 wherein the undesired angiogensis occurs in macular degeneration.
3. The method of claim 1 wherein the undesired angiogensis occurs in age-related macular degeneration.
4. The method of claim 1 wherein the amount administered is between approximately 0.1 and approximately 300 mg/kg/day.
5. The method of claim 4 wherein the amount administered is between approximately 0.5 and approximately 50 mg/kg/day.
6. The method of claim 5 wherein the amount administered is between approximately 1 and approximately 10 mg/kg/day.
7. The method of claim 1 wherein the compound is administered in the form of a tablet.
8. The method of claim 1 wherein the compound is administered in the form of a capsule.
9. The method of claim 1 wherein the compound is administered in the form of a lozenge, a cachet, a solution, a suspension, an emulsion, a powder, an aerosol, a suppository, a spray, a pastille, an ointment, a cream, a paste, a foam, a gel, a tamport, or a pessary.
10. The method of claim 1 wherein the administration is oral.
11. The method of claim 1 wherein the administration is sublingual, buccal, rectal, vaginal, or nasal.
12. The method of claim 1 wherein the administration is parenteral.
13. The method of claim 1 wherein the administration is transdermal or topical.
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