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Generated: December 15, 2017

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Title: Methods and compositions for inhibition of angiogenesis
Abstract:The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, the invention comprise the compound EM-138 and its use in the inhibition of angiogenesis and treatment of angiogenesis associate diseases, including the inhibition of tumor growth and metastasis.
Inventor(s): Green; Shawn J. (Vienna, VA), Swartz, Jr.; Glenn M. (Jessup, MD), Shah; Jamshed H. (Columbia, MD), Madsen; John (Knoxville, MD), D'Amato; Robert J. (Cambridge, MA)
Assignee: The Children's Medical Center (Cambridge, MA)
Filing Date:Mar 26, 1999
Application Number:09/277,402
Claims:1. A method of treating an eye condition associated with angiogenesis in a human or animal comprising administering to said human or animal an angiogenesis inhibiting amount of EM-138, ##STR19##

2. The method of claim 1 wherein the undesired angiogensis occurs in macular degeneration.

3. The method of claim 1 wherein the undesired angiogensis occurs in age-related macular degeneration.

4. The method of claim 1 wherein the amount administered is between approximately 0.1 and approximately 300 mg/kg/day.

5. The method of claim 4 wherein the amount administered is between approximately 0.5 and approximately 50 mg/kg/day.

6. The method of claim 5 wherein the amount administered is between approximately 1 and approximately 10 mg/kg/day.

7. The method of claim 1 wherein the compound is administered in the form of a tablet.

8. The method of claim 1 wherein the compound is administered in the form of a capsule.

9. The method of claim 1 wherein the compound is administered in the form of a lozenge, a cachet, a solution, a suspension, an emulsion, a powder, an aerosol, a suppository, a spray, a pastille, an ointment, a cream, a paste, a foam, a gel, a tamport, or a pessary.

10. The method of claim 1 wherein the administration is oral.

11. The method of claim 1 wherein the administration is sublingual, buccal, rectal, vaginal, or nasal.

12. The method of claim 1 wherein the administration is parenteral.

13. The method of claim 1 wherein the administration is transdermal or topical.
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Healthtrust

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