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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Cantor Fitzgerald
Fuji
Fish and Richardson
Cerilliant
Express Scripts
Merck
AstraZeneca
Chinese Patent Office
Cipla

Generated: February 22, 2018

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Title: Pharmaceutical composition for angiotensin II-mediated diseases
Abstract:This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally esterified carboxyl group; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R.sup.2 ; and Y is a bond, --O--, --S(O)m-- (wherein m is 0, 1 or 2) or --N(R.sup.4)-- (wherein R.sup.4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
Inventor(s): Inada; Yoshiyuki (Kawanishi, JP), Kubo; Keiji (Riverside, CA)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Filing Date:May 04, 2000
Application Number:09/563,855
Claims:1. A pharmaceutical composition, which comprises (.+-.)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7 -carboxylate or a pharmaceutically acceptable salt thereof in combination with furosemide.

2. A pharmaceutical composition, which comprises 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7 -carboxylic acid or a pharmaceutically acceptable salt thereof in combination with furosemide.

3. A pharmaceutical composition, which comprises 2-ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]meth yl]-1H-benzimidazole-7-carboxylic acid or a pharmaceutically acceptable salt thereof in combination with furosemide.
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Serving leading biopharmaceutical companies globally:

Citi
Covington
Deloitte
Express Scripts
Fuji
Merck
Federal Trade Commission
Queensland Health
US Army
Colorcon

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