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Details for Patent: 6,225,341

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Details for Patent: 6,225,341

Title: Compounds and methods for synthesis and therapy
Abstract:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
Inventor(s): Bischofberger; Norbert W. (San Carlos, CA), Kim; Choung U. (San Carlos, CA), Lew; Willard (San Mateo, CA), Liu; Hongtao (Foster City, CA), Williams; Matthew A. (Foster City, CA)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Filing Date:Apr 08, 1999
Application Number:09/288,091
Claims:1. A compound having the formula: ##STR968##

wherein:

T.sub.1 is --NHC(O)CH.sub.3, --NHC(O)CH.sub.2 F, --NHC(O)CHF.sub.2, or --NHC(O)CF.sub.3 ;

G.sub.1 is guanidino, amino, or guanidino or amino substituted with C.sub.1 -C.sub.5 alkyl;

U.sub.1 is C.sub.1 -C.sub.3 alkyl substituted with 1 to 3 C.sub.2 -C.sub.12 alkoxy groups; and E.sub.1 is COOH.

2. A method for the treatment or prophylaxis of virus infection in a host comprising administering to the host in need thereof a therapeutically effective amount of a compound having the formula: ##STR969##

wherein:

T.sub.1 is --NHC(O)CH.sub.3, --NHC(O)CH.sub.2 F, --NHC(O)CHF.sub.2, or --NHC(O)CF.sub.3 ;

G.sub.1 is guanidino, amino, or guanidino or amino substituted with C.sub.1 -C.sub.5 alkyl;

U.sub.1 is C.sub.1 -C.sub.3 alkyl substituted with 1 to 3 C.sub.1 -C.sub.12 alkoxy groups; and E.sub.1 is COOH.
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