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Details for Patent: 6,197,808

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Details for Patent: 6,197,808

Title: Methods for treating hyperplasia
Abstract:A method for a treatment of hyperplasia caused by papilloma virus, such as Condyloma acuminata, which comprises concomitantly topically and orally administering at least one tea catechin. Tea catechins do not involve the risk of side-effects and may be easily administered by the patients themselves.
Inventor(s): Cheng; Shu Jun (Beijing, CN), Wang; De Chang (Beijing, CN), Hara; Yukihiko (Fujieda, JP), Lee; Insu P. (Seoul, KR), Ahn; Woong Shick (Seoul, KR)
Assignee: Cancer Instititute (Hospital), Chinese Academy of Medical Sciences (Beijing, CN) Mitsui Norin Co., Ltd. (Tokyo, JP)
Filing Date:Oct 15, 1999
Application Number:09/418,890
Claims:1. A method for treating hyperplasia caused by a papilloma virus comprising both topically and orally administering to a human in need thereof a composition which comprises at least one tea catechin in an effective anti-hyperplasia amount.

2. The method according to claim 1, wherein tea catechin comprises (-)-epigallocatechin gallate.

3. The method according to claim 1, wherein said composition for topical administration is in the form of an ointment.

4. The method according to claim 2, wherein said composition for topical administration is in the form of an ointment.

5. The method according to claim 1, wherein said composition for topical administration is in the form of a suppository.

6. The method according to claim 2, wherein said composition for topical administration is in the form of a suppository.

7. The method of claim 3, wherein the tea catechin is in an amount of 2 to 20% by weight.

8. The method of claim 3, wherein the tea catechin is in an amount of 5 to 20% by weight.

9. The method of claim 3, wherein the tea catechin is in an amount of 15% by weight.

10. The method of claim 8, wherein the composition for topical administration comprises vaseline as a base to form a cream.

11. The method of claim 10, wherein the cream is topically applied to external genital organs.

12. The method of claim 5, wherein the suppository contains 50 to 500 mg by weight of the tea catechin.

13. The method of claim 5, wherein the suppository contains 200 to 300 mg by weight of the tea catechin.

14. The method of claim 5, wherein the suppository contains 250 mg of the tea catechin.

15. The method according to claim 13, wherein the suppository is applied to the vagina of a human.

16. The method of claim 1, wherein the composition is topically applied to an infected area on a human.

17. The method according to claim 16, wherein the infected area is the vagina.

18. The method according to claim 16, wherein the infected area is an external genital organ.

19. The method according to claim 16, wherein the infected area is the cervix.

20. The method according to claim 1, wherein the papilloma virus causes Condyloma acuminata.

21. The method according to claim 1, wherein the papilloma virus causes cervical intra-epithelial neoplasia.
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