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Generated: February 21, 2018

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Title: Oral 2-methyl-thieno-benzodiazepine formulation
Abstract:The invention provides a pharmaceutically acceptable solid oral formulation of olanzapine and a process for making such formulation.
Inventor(s): Cochran; George Randall (Indianapolis, IN), Morris; Tommy Clifford (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Aug 31, 1998
Application Number:09/144,188
Claims:1. A solid oral formulation consisting essentially of olanzapine as an active ingredient intimately mixed with lactose, hydroxypropyl cellulose, crospovidone, microcrystalline cellulose, and magnesium stearate; wherein said solid oral formulation is coated with hydroxypropyl methyl cellulose, said hydroxypropyl methyl cellulose is further coated with an aqueous dispersion film coat and said solid oral formulation is imprinted using an edible ink.

2. A formulation as claimed in claim 1 wherein Olanzapine is substantially pure Form II polymorph having a typical X-ray powder diffraction pattern as represented by the following interplanar spacings

TBL d 10.2689 8.577 7.4721 7.125 6.1459 6.071 5.4849 5.2181 5.1251 4.9874 4.7665 4.7158 4.4787 4.3307 4.2294 4.141 3.9873 3.7206 3.5645 3.5366 3.3828 3.2516 3.134 3.0848 3.0638 3.0111 2.8739 2.8102 2.7217 2.6432 2.6007.
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Serving leading biopharmaceutical companies globally:

Chinese Patent Office
Queensland Health
US Department of Justice
Boehringer Ingelheim
Johnson and Johnson
Fish and Richardson
Express Scripts

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