Generated: May 22, 2017
|Title:||Oral 2-methyl-thieno-benzodiazepine formulation|
|Abstract:||The invention provides a pharmaceutically acceptable solid oral formulation of olanzapine and a process for making such formulation.|
|Inventor(s):||Cochran; George Randall (Indianapolis, IN), Morris; Tommy Clifford (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
|Filing Date:||Aug 31, 1998|
|Claims:||1. A solid oral formulation consisting essentially of olanzapine as an active ingredient intimately mixed with lactose, hydroxypropyl cellulose, crospovidone, microcrystalline cellulose, and magnesium stearate; wherein said solid oral formulation is coated with hydroxypropyl methyl cellulose, said hydroxypropyl methyl cellulose is further coated with an aqueous dispersion film coat and said solid oral formulation is imprinted using an edible ink. |
2. A formulation as claimed in claim 1 wherein Olanzapine is substantially pure Form II polymorph having a typical X-ray powder diffraction pattern as represented by the following interplanar spacings
TBL d 10.2689 8.577 7.4721 7.125 6.1459 6.071 5.4849 5.2181 5.1251 4.9874 4.7665 4.7158 4.4787 4.3307 4.2294 4.141 3.9873 3.7206 3.5645 3.5366 3.3828 3.2516 3.134 3.0848 3.0638 3.0111 2.8739 2.8102 2.7217 2.6432 2.6007.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.