Details for Patent: 6,180,781

Title:	Process for making mometasone furoate monohydrate
Abstract:	The invention relates to the novel compound mometasone furoate monohydrate, process for its preparation and pharmaceutical compositions containing said compound.
Inventor(s):	Yuen; Pui-Ho (Princeton Junction, NJ), Eckhart; Charles (Kenilworth, NJ), Etlinger; Teresa (Bloomfield, NJ), Levine; Nancy (Flemington, NJ)
Assignee:	Schering Corporation (Kenilworth, NJ)
Filing Date:	Apr 17, 1995
Application Number:	08/422,479
Claims:	1. A process for preparing mometasone furoate monohydrate which comprises: (a) forming a saturated water-miscible organic solvent solution of mometasone furoate; (b) adding sufficient water to form a solvent mixture ratio of at least 1:1 (water:organic solvent); and (c) recovering a monohydrate product. 2. The process of claim 1 wherein the organic solvent is selected from the group consisting of ethanol, isopropanol, acetone, dioxane and ethyl acetate. 3. A process for preparing mometasone furoate monohydrate, comprising: (a) forming a saturated solution of mometasone furoate in a water-miscible organic solvent; (b) adding to the solution an equal or greater volume of water; and (c) recovering a monohydrate product. 4. The process of claim 3, wherein the organic solvent is selected from the group consisting of alcohols, ketones. ethers, esters and mixtures of any two or more thereof. 5. The process of claim 3, wherein the organic solvent is selected from the group consisting of ethanol, isopropanol, acetone, dioxane, ethyl acetate and mixtures of any two or more thereof. 6. The process of claim 3, wherein the organic solvent comprises acetone or isopropanol. 7. The process of claim 3, wherein the mometasone furoate monohydrate product is recovered in a yield at least about 90 percent by weight.