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Details for Patent: 6,168,587

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Details for Patent: 6,168,587

Title: Needleless syringe using supersonic gas flow for particle delivery
Abstract:A needleless syringe having a membrane (28) which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.
Inventor(s): Bellhouse; Brian J. (Islip, GB), Sarphie; David F. (Oxford, GB), Greenford; John C. (Abingdon, GB)
Assignee: PowderJect Research Limited (GB)
Filing Date:Dec 05, 1997
Application Number:08/986,124
Claims:1. A method for vaccinating a mammalian subject, said method comprising delivering particles of a powdered agent to said subject via transdermal needleless administration.

2. The method of claim 1, wherein said powdered agent comprises a viral immunogen.

3. The method of claim 2, wherein said powdered agent is a subunit vaccine composition.

4. The method of claim 3, wherein said viral immunogen is a viral protein.

5. The method of claim 3, wherein said viral immunogen is derived from Hepatitis type A.

6. The method of claim 2, wherein said viral immunogen is a viral particle.

7. The method of claim 1, wherein said powdered agent comprises a bacterial immunogen.

8. The method of claim 7, wherein said powdered agent is a subunit vaccine composition.

9. The method of claim 7, wherein said bacterial immunogen is derived from a meningitis immunogen.

10. The method of claim 1, wherein said powdered agent comprises a live, attenuated organism.

11. The method of claim 10, wherein the attenuated organism is a bacterium.

12. The method of claim 11, wherein the attenuated bacterium is Mycobacterium tuberculosis strain Bacille, Calmette, Guerin (BCG).

13. The method of claim 1 wherein the powdered agent is administered sub-cutaneously.

14. The method of claim 1 wherein the powdered agent is administered intra-dermally.

15. The method of claim 1 wherein the powdered agent is administered intra-muscularly.

16. The method of claim 1 wherein the powdered agent comprises a substantially inert carrier.

17. The method of claim 1 wherein the powdered agent comprises a diluent.

18. The method of claim 1 wherein the powdered agent comprises a density-enhancing agent.

19. The method of claim 1 wherein the mammalian subject is human.

20. The method of claim 1 wherein the particles of the powdered agent are delivered to the locus of transdermal needleless administration at a velocity in the range of between 200 and 2,500 m/sec.

21. The method of claim 1 wherein the particles of the powdered agent have a size predominantly in the range of about 0.1 to 250 .mu.m.

22. The method of claim 1 wherein the particles of the powdered agent have a density in the range of 0.48 to 25 g/cm.sup.3.
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