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Generated: February 21, 2018

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Title: Method and compositions for the synthesis of BCH-189 and related compounds
Abstract:The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched .beta.-BCH-189 and its analogs.
Inventor(s): Liotta; Dennis C. (McDonough, GA), Choi; Woo-Baeg (North Brunswick, NJ)
Assignee: Emory University (Atlanta, GA)
Filing Date:Jun 22, 1999
Application Number:09/337,910
Claims:1. A method of preparing the B-isomer of a 1,3-oxathiolane nucleoside, comprising reacting a compound of the structure: ##STR8## wherein R' is an acyl group and R is an oxygen protecting group, with a protected pyrimidine base in the presence of SnCl.sub.4.
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