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Details for Patent: 6,143,799

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Details for Patent: 6,143,799

Title: Use of borate-polyol complexes in ophthalmic compositions
Abstract:Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
Inventor(s): Chowhan; Masood (Arlington, TX), Dassanayake; Nissanke L. (Arlington, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Filing Date:Jul 02, 1998
Application Number:09/109,453
Claims:1. In a method of preserving an aqueous ophthalmic composition from microbial contamination, the improvement which comprises including 0.5 to 6.0 wt % of a water-soluble borate-polyol complex in the composition, said complex containing borate and polyol in a molar ratio of 1:0.1 to 1:10, whereby the antimicrobial activity of the composition is enhanced.

2. A method according to claim 1, wherein the composition contains a preservative effective amount of an ophthalmically acceptable antimicrobial agent.

3. A method according to claim 2, wherein the antimicrobial agent is selected from the group consisting of monomeric and polymeric quaternary ammonium compounds and their ophthalmically acceptable salts, monomeric and polymeric biguanides and their ophthalmically acceptable salts, and combinations thereof.

4. A method according to claim 3, wherein the borate-polyol complex is included in the composition in a concentration of 1.0 to 2.5 wt %, and the molar ratio of borate to polyol is 1:0.25 to 1:2.5.

5. A method according to claim 4, wherein the polyol is mannitol.

6. A method according to claim 5, wherein the antimicrobial agent comprises a polymeric quaternary ammonium compound.

7. A method according to claim 6, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

8. A method according to claim 7, wherein the concentration of polyquaternium- 1 in the composition is up to 0.001 wt %.

9. A method according to claim 5 wherein the antimicrobial agent comprises a polymeric biguanide.

10. A method according to claim 9, wherein polymeric biguanide is polyhexamethylene biguanide.

11. A saline solution for soaking, rinsing and storing contact lenses, comprising:

an amount of a borate-polyol complex sufficient to preserve the solution from microbial contamination, said complex containing borate and polyol in a molar ratio of 1:0.1 to 1:1;

an amount of an osmolality-building agent sufficient to render the solution isotonic; and

water.

12. A solution according to claim 11, wherein the solution comprises 0.5 to 6.0 wt % of the borate-polyol complex, and the molar ratio of borate to polyol is 1:0.25 to 1:0.75.

13. A solution according to claim 12, wherein the polyol is mannitol.

14. An aqueous solution for disinfecting contact lenses, comprising:

a disinfecting amount of an ophthalmically acceptable antimicrobial agent;

an amount of a borate-polyol complex sufficient to enhance the antimicrobial efficacy of the antimicrobial agent, said complex containing borate and polyol in a molar ratio of 1:0.1 to 1:10;

an amount of an osmolality-building agent sufficient to render the solution isotonic; and

water.

15. A solution according to claim 14, wherein the polyol is mannitol.

16. A solution according to claim 14, wherein the antimicrobial agent is selected from the group consisting of polymeric quaternary ammonium compounds and polymeric biguanides.

17. A solution according to claim 16, wherein the antimicrobial agent is a polymeric quaternary ammonium compound.

18. A solution according to claim 17, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

19. A solution according to claim 18, wherein the solution contains polyquaternium-1 in a concentration of 0.001 wt %.

20. A solution according to claim 16, wherein the antimicrobial agent is a polymeric biguanide.

21. A solution according to claim 20, wherein the polymeric biguanide is polyhexamethylene biguanide.
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