|Title:||GABA and L-glutamic acid analogs for antiseizure treatment|
|Abstract:||A compound of the formula ##STR1## wherein R.sub.1 is a straight branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.|
|Inventor(s):||Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI)|
|Assignee:||Northwestern University (Evanston, IL) Warner-Lambert Company (Ann Arbor, MI)|
|Filing Date:||Feb 04, 1999|
|Claims:||1. A method of treating a patient having cerebral ischemia which includes administering to a patient from about 1 mg to about 300 mg/kg of the compound [R-(-)]4-amino-3-(2-methylpropyl) butanoic acid. |
2. A method of treating a patient having cerebral ischemia which includes administering to a patient from about 1 mg to about 300 mg/kg of the compound S-(+)4-amino-3-(2-methylpropyl) butanoic acid.