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Details for Patent: 6,136,298

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Details for Patent: 6,136,298

Title: Process for inhibiting S. mutans and caries
Abstract:A process which inhibits bacteria and caries comprising the application of an oral composition containing a substantially water insoluble noncationic antimicrobial agent, such as triclosan, xylitol, and sodium lauryl sulfate as the surfactant and dispersant for the water insoluble noncationic antimicrobial agent.
Inventor(s): Gaffar; Abdul (Princeton, NJ), Nabi; Nuran (Cranbury, NJ), Afflitto; John J. (Brookside, NJ)
Assignee: Colgate-Palmolive Company (New York, NY)
Filing Date:Jan 20, 1999
Application Number:09/234,246
Claims:1. A process of reducing caries formation comprising preparing an antibacterial oral composition which is free of a fluoride ion releasing compound and contains an effective antiplaque amount of a substantially water insoluble noncationic antimicrobial agent, at least about 0.1% by weight of xylitol, and at least 0.5% sodium lauryl sulfate, and an antibacterial-enhancing agent, applying the antibacterial oral composition to the oral surfaces and thereby inhibiting the growth of streptococcus mutans.

2. The process claimed in claim 1 wherein said antibacterial agent is present in amount of about 0.01-5% by weight.

3. The process claimed in claim 2 wherein said antibacterial agent is triclosan.

4. The process claimed in claim 3 wherein said amount of said antibacterial agent is about 0.3-0.5% by weight.

5. The process claimed in claim 1 wherein xylitol is present in amount of about 0.1-5% by weight.

6. The process claimed in claim 1 wherein xylitol is present in amount of about 3-25% by weight.

7. The process claimed in claim 6 wherein xylitol is present in amount of about 5-20% by weight.

8. The process claimed in claim 1 wherein xylitol is present in amount of about 20-40% by weight.

9. The process claimed in claim 1 wherein said antibacterial-enhancing agent is a polycarboxylate.

10. The process claimed in claim 1 wherein said process additionally comprises about 0.1-5% by weight of a flavoring oil.

11. The process claimed in claim 1, wherein said antibacterial agent is selected from the group consisting of halogenated diphenyl ethers, benzoic acids, halogenated carbanilides and phenolic compounds.

12. The process claimed in claim 11, wherein said antibacterial agent is a halogenated diphenyl ether.

13. The process of claim 9 wherein the polycarboxylate is a maleic anhydride/methyl vinyl ether copolymer.

14. The process of claim 1 wherein the oral composition is a mouth rinse.

15. The process of claim 1 wherein the oral composition is a dental paste.

16. The process of claim 1 wherein the oral composition is a dental gel.
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