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Express Scripts
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Federal Trade Commission

Generated: June 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,124,449

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Title: High affinity TGF.beta. nucleic acid ligands and inhibitors
Abstract:Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.. Included in the invention are specific RNA ligands to TGF.beta.1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.1 with its receptor.
Inventor(s): Gold; Larry (Boulder, CO), Pagratis; Nikos (Boulder, CO)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Filing Date:Mar 23, 1998
Application Number:09/046,247
Claims:1. A purified and isolated non-naturally occurring RNA ligand to TGF.beta.1 wherein said ligand is selected from the group consisting of the sequences set forth in Table 3 (SEQ ID NOS: 6-143).

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