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Serving 500+ biopharmaceutical companies globally:

UBS
Colorcon
US Department of Justice
McKinsey
Queensland Health
Boehringer Ingelheim
Citi
Federal Trade Commission
Covington
AstraZeneca

Generated: June 22, 2017

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Details for Patent: 6,117,414

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Details for Patent: 6,117,414

Title: Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents
Abstract:Novel gas filled microspheres useful as computed tomography (CT) contrast agents. The microspheres are prepared from a gas and/or a gaseous precursor, and one or more stabilizing compounds.
Inventor(s): Unger; Evan C. (Tucson, AZ)
Assignee: ImaRx Pharmaceutical Corp. (Tucson, AZ)
Filing Date:Nov 10, 1997
Application Number:08/968,776
Claims:1. A method of providing an image of an internal region of a patient comprising (i) administering to the patient a composition comprising, in an aqueous carrier, gas-filled microspheres, wherein said gas comprises a fluorinated gas selected from the group consisting of perfluorocarbons and sulfur hexafluoride, and said microspheres comprise a biocompatible lipid, bearing a hydrophilic polymer, said hydrophilic polymer covalently bound to said biocompatible lipid through an amide, carbamate, amine, ester, ether thioester or thioamide linkage, and (ii) scanning the patient using computed tomography to obtain visible images of the region.

2. A method according to claim 1 wherein the region comprises the vasculature.

3. A method according to claim 1 wherein the region comprises the cardiovascular region.

4. A method according to claim 1 wherein the region comprises the gastrointestinal region.

5. A method for diagnosing the presence of diseased tissue in a patient comprising (i) administering to the patient a composition comprising, in an aqueous carrier, gas-filled microspheres, wherein said gas comprises a fluorinated gas selected from the group consisting of perfluorocarbons and sulfur hexafluoride, and said microspheres comprise a biocompatible lipid bearing a hydrophilic polymer, said hydrophilic polymer covalently bound to said biocompatible lipid through an amide, carbamate, amine, ester, ether, thioester or thioamide region.

6. A method according to claim 5 wherein the region comprises the vasculature.

7. A method according to claim 5 wherein the region comprises the cardiovascular region.

8. A method according to claim 5 wherein the region comprises the gastrointestinal region.

9. A method according to claim 5 wherein said scanning is of a region of a patient selected from the group consisting of the intranasal tract, the auditory canal, the intraocular region, the intraperitoneal region, the kidneys, the urethra and the genitourinary tract.
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Serving 500+ biopharmaceutical companies globally:

Covington
Cerilliant
Fish and Richardson
Cipla
McKesson
Daiichi Sankyo
Moodys
Cantor Fitzgerald
Express Scripts
Merck

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