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Details for Patent: 6,103,701

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Details for Patent: 6,103,701

Title: Method for enhancing hematopoiesis with acyl deoxyribonucleosides
Abstract:The invention relates to compositions comprising acyl derivatives of 2'-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
Inventor(s): von Borstel; Reid Warren (Darnestown, MD), Bamat; Michael Kevin (Darnestown, MD)
Assignee:
Filing Date:Jun 06, 1995
Application Number:08/470,027
Claims:1. A method of enhancing hematopoiesis in an animal in need of such treatment comprising administering to said animal a hematopoiesis stimulating amount of one or more compounds selected from the group consisting of ##STR19## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl group derived from

(a) an unbranched fatty acid with 2 to 22 carbon atoms,

(b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,

(c) nicotinic acid, or

(d) a dicarboxylic acid having 3 to 22 carbon atoms,

provided that not all of R.sub.1, R.sub.2, and R.sub.3 are H, or a pharmaceutically acceptable salt thereof.

2. A method as in claim 1 wherein said compound is ##STR20## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl group derived from

(a) an unbranched fatty acid with 2 to 22 carbon atoms,

(b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,

(c) nicotinic acid, or

(d) a dicarboxylic acid having 3 to 22 carbon atoms,

provided that not all of R.sub.1, R.sub.2, and R.sub.3 are H, or a pharmaceutically acceptable salt thereof.

3. A method as in claim 1 wherein said compound is ##STR21## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl group derived from

(a) an unbranched fatty acid with 2 to 22 carbon atoms,

(b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, camitine, and ornithine,

(c) nicotinic acid, or

(d) a dicarboxylic acid having 3 to 22 carbon atoms,

provided that not all of R.sub.1, R.sub.2, and R.sub.3 are H, or a pharmaceutically acceptable salt thereof.

4. A method as in claim 1 wherein said compound is ##STR22## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl group derived from

(a) an unbranched fatty acid with 2 to 22 carbon atoms,

(b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyprolne, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,

(c) nicotinic acid, or

(d) a dicarboxylic acid having 3 to 22 carbon atoms,

provided that not all of R.sub.1, R.sub.2, and R.sub.3 are H, or a pharmaceutically acceptable salt thereof.

5. A method as in claim 1 wherein said compound is ##STR23## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each is hydrogen or an acyl group derived from

(a) an unbranched fatty acid with 2 to 22 carbon atoms,

(b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,

(c) nicotinic acid, or

(d) a dicarboxylic acid having 3 to 22 carbon atoms,

provided that not all of R.sub.1, R.sub.2, and R.sub.3 are H, or a pharmaceutically acceptable salt thereof.

6. A method as in claim 2 wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is an unbranched fatty acid with 3-22 carbon atoms.

7. A method as in claim 3 wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is an unbranched fatty acid with 3-22 carbon atoms.

8. A method as in claim 4 wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is an unbranched fatty acid with 3-22 carbon atoms.

9. A method as in claim 5 wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is an unbranched fatty acid with 3-22 carbon atoms.
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