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Details for Patent: 6,093,794

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Details for Patent: 6,093,794

Title: Isolated peptides derived from the Epstein-Barr virus containing fusion inhibitory domains
Abstract:The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
Inventor(s): Barney; Shawn O'Lin (Cary, NC), Lambert; Dennis Michael (Cary, NC), Petteway; Stephen Robert (Cary, NC)
Assignee: Trimeris, Inc. (Durham, NC)
Filing Date:Jun 07, 1995
Application Number:08/471,913
Claims:1. An isolated peptide consisting of an amino acid sequence of a 16 to 39 amino acid residue region of an Epstein-Barr virus protein, wherein said region is identified by an ALLMOTI5, 107.times.178.times.4, or PLZIP sequence search motif, said peptide further consists of an amino terminal X, and a carboxy terminal Z in which:

X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group a hydrophobic group, or a macromolecular carrier group; and

Z comprises a carboxyl group, an amido group a hydrophobic group, or a macromolecular carrier group.

2. An isolated peptide having the formula:

or

in which:

amino acid residues are presented by the single-letter code;

X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecular carrier group;

Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.

3. The peptide of claim 1 or 2 wherein X is a hydrophobic group.

4. The peptide of claim 3 wherein the hydrophobic group X is carbobenzoxyl, dansyl, or t-butyloxycarbonyl.

5. The peptide of claim 1 or 2 wherein Z is a hydrophobic group.

6. The peptide of claim 5 wherein the hydrophobic group Z is t-butyloxycarbonyl.

7. The peptide of claim 1 or 2 wherein X is a macromolecular carrier group.

8. The peptide of claim 7 wherein the macromolecular carrier group is a lipid-fatty acid conjugate, a polyethylene glycol, or a carbohydrate moiety.

9. The peptide of claim 1 or 2 wherein Z is a macromolecular carrier group.

10. The peptide of claim 9 wherein the macromolecular carrier group Z is a lipid-fatty acid conjugate, a polyethylene glycol, or a carbohydrate moiety.

11. The peptide of claim 1 or 2 wherein at least one bond linking adjacent amino acid residues is a non-peptide bond.

12. The peptide of claim 11 wherein the non-peptide bond is an imino, ester, hydrazine, semicarbazide, or azo bond.

13. The peptide of claim 1 or 2 wherein at least one amino acid residue is in a D-isomer configuration.

14. The peptide of claim 7 wherein the macromolecular group is a peptide group.

15. The peptide of claim 14 wherein the peptide group is about 2 to about 50 amino acid residues amino to the Epstein-Barr virus protein identified by the ALLMOTI5, 107.times.178.times.4, or PLZIP sequence search motif.

16. The peptide of claim 9 wherein the macromolecular group is a peptide group.

17. The peptide of claim 16 wherein the peptide group is about 2 to about 50 amino acid residues amino to the Epstein-Barr virus protein identified by the ALLMOTI5, 107.times.178.times.4, or PLZIP sequence search motif.

18. The peptide of claim 1 wherein the region of the Epstein-Barr virus protein consists of a region of 28 amino acid residues identified by the ALLMOTI5 sequence search motif.

19. The peptide of claim 1 wherein the region of the Epstein-Barr virus protein consists of a region of 35 amino acid residues identified by the ALLMOTI5 sequence search motif.

20. The peptide of claim 1 wherein the region of the Epstein-Barr virus protein consists of a region of 28 amino acid residues identified by the 107.times.178.times.4 sequence search motif.

21. The peptide of claim 1 wherein the region of the Epstein-Barr virus protein consists of a region of 35 amino acid residues identified by the 107.times.178.times.4 sequence search motif.

22. The peptide of claim 1 wherein the region of the Epstein-Barr virus protein is identified by the PLZIP sequence search motif.

23. The peptide of claim 2 wherein the peptide has the formula:

24. The peptide of claim 2 wherein the peptide has the formula:

25. The peptide of claim 2 wherein the peptide has the formula:

26. The peptide of claim 2 wherein the peptide has the formula:

27. The peptide of claim 2 wherein the peptide has the formula:
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