|Title:|| Thrombus imaging agents|
|Abstract:||This invention relates to radiolabeled reagents that are scintigraphic imaging agents for imaging sites of thrombus formation in vivo, and methods for producing such reagents. Specifically, the invention relates to reagents each comprised of a specific binding compound, capable of binding to at least one component of a thrombus, covalently linked to a radiolabel-binding moiety. The invention provides these reagents, methods and kits for making such reagents, and methods for using such reagents labeled with technetium-99m to image thrombus sites in a mammalian body.|
|Inventor(s):|| Dean; Richard T. (Bedford, NH), Lister-James; John (Bedford, NH) |
|Assignee:|| Diatide, Inc. (Londonderry, NH) |
|Filing Date:||Aug 27, 1998|
|Claims:||1. A composition comprising technetium-99m and a reagent having a formula: ##STR12## |
2. A complex having a structure:
3. A method of imaging a thrombus in a mammalian body comprising the steps of a) administering to said body an effective diagnostic amount of an imaging agent comprising technetium-99m and a reagent having a formula: ##STR13## and b) detecting technetium-99m localized at said thrombus.