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|Title:||Method of preventing NMDA receptor complex-mediated neuronal damage|
|Abstract:||Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.|
|Inventor(s):||Lipton; Stuart A. (Newton, MA), Stamler; Jonathan (Chapel Hill, NC)|
|Assignee:||Children's Medical Center Corporation (Boston, MA)|
|Filing Date:||Aug 21, 1998|
|Claims:||1. A method of decreasing NMDA receptor-mediated neuronal damage in a mammal comprising administering to a patient a composition comprising a component selected from the group consisting of: superoxide dismuta se (SOD); an SOD mimic; catalase; combinations of at least two ingredients, said first ingredient being SOD or said mimic and said second ingredient being catalase. |
2. The method of claim wherein said patient is infected with a human immunodeficiency virus (HIV) and said method treats neurological manifestations of HIV infection.
3. The method of claim 1 wherein said patient suffers from amyotrophic lateral sclerosis (ALS) and said method treats neurological manifestations of ALS.
4. The method of claim 1 wherein said patient suffers from neuropathic pain mediated by NMDA receptor activity.
5. The method of any one of claims 1-4, wherein said component is formulated in polyethylene glycol or liposomes to enhance central nervous system absorption and efficacy.