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|Title:||Methods for inhibition of membrane fusion-associated events, including influenza virus|
|Abstract:||The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.|
|Inventor(s):||Barney; Shawn O'Lin (Cary, NC), Lambert; Dennis Michael (Cary, NC), Petteway; Stephen Robert (Cary, NC)|
|Assignee:||Trimeris, Inc. (Durham, NC)|
|Filing Date:||Jun 07, 1995|
|Claims:||1. A method for the inhibition of transmission of an influenza A virus to a cell, comprising contacting the cell with an effective concentration of an influenza virus peptide, said peptide identified through the use of a computer algorithm which utilizes an ALLMOTI5, 107x178x4 or a PLZIP sequence search motif, for an effective period of time so that no infection of the cell by the virus occurs. |
2. A method for the inhibition of transmission of an influenza A virus to a cell, comprising contacting the cell with an effective concentration of a peptide having the formula:
X-QAAIDQINGKLNRVIEKTNEKFHQIEKEFS EVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTI-Z (SEQ ID NO. 210); or
X-AADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFS EVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLT-Z (SEQ ID NO. 211),
X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecule carrier group; and
Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.
3. The method of claim 2 wherein the peptide has the formula:
X-QAAIDQINGKLNRVIEKTNEKFHQIEKEFS EVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTI-Z (SEQ ID NO. 210).
4. The method of claim 2 wherein the peptide has the formula:
X-AADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFS EVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLT-Z (SEQ ID NO. 211).
5. The method of claim 2, 3, or 4 wherein X is an acetyl group, and Z is an amido group.
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