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|Title:||Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in the treatment of various disorders|
|Abstract:||Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain .beta.-hemoglobinopathies, anemia, and cancer.|
|Inventor(s):||Brusilow; Saul W. (Baltimore, MD)|
|Assignee:||Brusilow Enterprises LLC (Baltimore, MD)|
|Filing Date:||May 25, 1999|
|Claims:||1. A method for the treatment of beta-hemoglobinopathies comprising administering to a patient in need of such treatment an effective amount of a compound of formula I ##STR7## wherein R.sub.1, R.sub.2, and R.sub.3 are independently, H, ##STR8## or ##STR9## and n is zero or an even number, m is an even number and east one of R.sub.1, R.sub.2, and R.sub.3 is not H. |
2. A method for the treatment of beta-hemoglobinopathies comprising administering to a patient in need of such treatment an effective amount of a compound of formula II ##STR10## wherein R.sub.4 is ##STR11## or ##STR12## wherein n is zero or an even number and m is an even number.
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