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|Title:||Compositions for inhibition of membrane fusion-associated events, including influenza virus transmission|
|Abstract:||The present invention relates to viral peptides referred to as "DP107- and DP178-like" peptides. Specifically, the invention relates to isolated influenza A DP107- and DP178-like peptides which are identified by sequence search motif algorithms. The peptides of the invention exhibit antiviral activity believed to result from inhibition of viral induced fusogenic events.|
|Inventor(s):||Barney; Shawn O'Lin (Cary, NC), Lambert; Dennis Michael (Cary, NC), Petteway; Stephen Robert (Cary, NC)|
|Assignee:||Trimeris, Inc. (Durham, NC) Duke University (Durham, NC)|
|Filing Date:||Jun 07, 1995|
|Claims:||1. An isolated peptide region of an influenza A virus protein, said region comprising an amino acid sequence identified by an ALLMOT15, 107.times.178.times.4, or PLZIP sequence search motif. |
2. An isolated peptide of the formula
X-QAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTI-Z (SEQ ID NO. 210); or
X-AADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHT IDLT-Z (SEQ ID NO. 211),
X comprises an amino group, an acetyl group, a 9-fluoroenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecular carrier group; and
Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.
3. The peptide of claim 2 of the formula:
X-QAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTI-Z (SEQ ID NO. 210).
4. The peptide of claim 2 of the formula:
X-AADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHT IDLT-Z (SEQ ID NO. 211).
5. The peptide of claim 3 or 4, wherein X is an acetyl group and Z is an amido group.