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Details for Patent: 6,048,898

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Details for Patent: 6,048,898

Title: Copolymer-1 improvements in compositions of copolymers
Abstract:The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
Inventor(s): Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)
Assignee: Yeda Research and Development Co., Ltd. (Rehovot, IL)
Filing Date:Feb 27, 1998
Application Number:09/032,334
Claims:1. A method of manufacturing copolymer-1 of a predetermined molecular weight profile, comprising the steps of:

selecting a predetermined molecular weight profile,

reacting protected copolymer-1 with hydrobromic acid to form trifluoroacetyl copolymer-1 having the predetermined molecular weight profile, wherein said reaction takes place for a time and at a temperature predetermined by test reaction, and

treating said trifluoroacetyl copolymer-1 having the predetermined molecular weight profile with aqueous piperidine solution to form copolymer-1 having the predetermined molecular weight profile.

2. The method of claim 1, wherein said protected copolymer-1 reacted with hydrobromic acid for about 10-50 hours at a temperature of about 20-28.degree. C.

3. The method of claim 2, wherein said protected copolymer-1 is reacted with hydrobromic acid for about 17 hours at a temperature of about 26.degree. C.

4. A method of manufacturing trifluoroacetyl copolymer-1 having a predetermined molecular weight profile, comprising the steps of:

selecting a predetermined molecular weight profile, and then

reacting protected copolymer-1 with hydrobromic acid for a time and at a temperature predetermined by test reaction to provide trifluoroacetly copolymer-1 having the predetermined molecular weight profile.

5. The method of claim 4, wherein said protected copolymer-1 is reacted with hydrobromic acid for about 10-50 hours at a temperature of about 20-28.degree. C.

6. The method of claim 5, wherein said protected copolymer-1 is reacted with hydrobromic acid for about 17 hours at a temperature of about 26.degree. C.
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