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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Federal Trade Commission
Queensland Health
Fish and Richardson

Generated: June 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,040,332

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Title: Amino ceramide-like compounds and therapeutic methods of use
Abstract:Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
Inventor(s): Shayman; James A. (Ann Arbor, MI), Radin; Norman S. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Filing Date:Jun 26, 1997
Application Number:08/882,773
Claims:1. A method for treating a patient having a microbial or viral infection comprising the step of administering to the patient a therapeutically effective amount of a compound selected from the group consisting of compounds of the formula: ##STR5## where R.sub.1 is an aromatic structure, an alicyclic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons;

R.sub.2 is an aliphatic chain having 9 to 18 carbons; and

R.sub.3 is pyrrolidino;

and functional homologues, isomers and pharmaceutically acceptable salts thereof.

2. The method of claim 1, where R.sub.1 is a phenyl group.

3. The method of claim 1, where R.sub.1 is p-methoxyphenyl.

4. The method of claim 1, where R.sub.2 is C.sub.15 H.sub.31.

5. The method of claim 1, where the compound is 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol and pharmaceutically acceptable salts thereof.

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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Queensland Health
Argus Health
US Department of Justice
Harvard Business School

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