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Serving hundreds of leading biopharmaceutical companies globally:

Covington
Teva
Cerilliant
McKesson
Baxter
Citi
US Department of Justice
Accenture
Healthtrust

Generated: April 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,030,995

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Title: Amino ceramide-like compounds and therapeutic methods of use
Abstract:Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
Inventor(s): Shayman; James A. (Ann Arbor, MI), Radin; Norman S. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Filing Date:Oct 29, 1998
Application Number:09/182,161
Claims:1. A compound selected from the group consisting of the formula: ##STR5## where R.sub.1 is an aromatic structure, an alicyclic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons;

R.sub.2 is an aliphatic chain having 10 to 18 carbons; and

R.sub.3 is pyrrolidino;

and functional homologues, isomers and pharmaceutically acceptable salts thereof.

2. The compound of claim 1, wherein R.sub.1 is a phenyl group.

3. The compound of claim 1, wherein R.sub.1 is p-methoxyphenyl.

4. The compound of claim 1, wherein R.sub.2 is C.sub.15 H.sub.31.

5. The compound of claim 1, where the compound is 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol and pharmaceutically acceptable salts thereof.

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Serving hundreds of leading biopharmaceutical companies globally:

Baxter
UBS
Julphar
Daiichi Sankyo
Merck
Fish and Richardson
Accenture
Citi
Healthtrust

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