Generated: April 29, 2017
|Title:||Amino ceramide-like compounds and therapeutic methods of use|
|Abstract:||Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.|
|Inventor(s):||Shayman; James A. (Ann Arbor, MI), Radin; Norman S. (Ann Arbor, MI)|
|Assignee:||The Regents of the University of Michigan (Ann Arbor, MI)|
|Filing Date:||Oct 29, 1998|
|Claims:||1. A compound selected from the group consisting of the formula: ##STR5## where R.sub.1 is an aromatic structure, an alicyclic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons; |
R.sub.2 is an aliphatic chain having 10 to 18 carbons; and
R.sub.3 is pyrrolidino;
and functional homologues, isomers and pharmaceutically acceptable salts thereof.
2. The compound of claim 1, wherein R.sub.1 is a phenyl group.
3. The compound of claim 1, wherein R.sub.1 is p-methoxyphenyl.
4. The compound of claim 1, wherein R.sub.2 is C.sub.15 H.sub.31.
5. The compound of claim 1, where the compound is 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol and pharmaceutically acceptable salts thereof.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.