|Title:|| Amino ceramide-like compounds and therapeutic methods of use|
|Abstract:||Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.|
|Inventor(s):|| Shayman; James A. (Ann Arbor, MI), Radin; Norman S. (Ann Arbor, MI) |
|Assignee:|| The Regents of the University of Michigan (Ann Arbor, MI) |
|Filing Date:||Oct 29, 1998|
|Claims:||1. A compound selected from the group consisting of the formula: ##STR5## where R.sub.1 is an aromatic structure, an alicyclic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons; |
R.sub.2 is an aliphatic chain having 10 to 18 carbons; and
R.sub.3 is pyrrolidino;
and functional homologues, isomers and pharmaceutically acceptable salts thereof.
2. The compound of claim 1, wherein R.sub.1 is a phenyl group.
3. The compound of claim 1, wherein R.sub.1 is p-methoxyphenyl.
4. The compound of claim 1, wherein R.sub.2 is C.sub.15 H.sub.31.
5. The compound of claim 1, where the compound is 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol and pharmaceutically acceptable salts thereof.