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Generated: August 20, 2017

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Title: GABA and L-glutamic acid analogs for antiseizure treatment
Abstract:A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.
Inventor(s): Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL), Yuen; Po-Wai (Ann Arbor, MI), Sobieray; Denis Martin (Holland, MI), Franklin; Lloyd Charles (Hamilton, MI), Schwindt; Mark Alan (Holland, MI)
Assignee: Northwestern University (Evanston, IL) Warner-Lambert Company (Ann Arbor, MI)
Filing Date:Apr 21, 1998
Application Number:09/063,834
Claims:1. A compound which is

3-(hydroxymethyl)-5-methyl-hexanoic acid, phenylmethyl ester.

2. A compound which is

3-(hydroxymethyl)-5-methyl-hexanoic acid, 1,1-dimethyl ester.
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Serving 500+ biopharmaceutical companies globally:

Fuji
Cantor Fitzgerald
Queensland Health
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Fish and Richardson
Teva
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McKesson
Deloitte
Medtronic

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