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Generated: February 23, 2018

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Title: 1.alpha.-hydroxy vitamin D.sub.4 and novel intermediates and analogues
Abstract:Disclosed is 1.alpha.,24-dihydroxy vitamin D.sub.4 having the following structure: ##STR1## and pharmaceutical compositions containing said compound. The compound and composition are useful in the treatment of abnormal calcium metabolism. Also Disclosed is a method for the preparation of 1.alpha.,24-dihydroxy vitamin D.sub.4.
Inventor(s): Knutson; Joyce C. (Madison, WI), Bishop; Charles W. (Verona, WI), Moriarty; Robert M. (Oak Park, IL)
Assignee: Bone Care International, Inc. (Madison, WI)
Filing Date:Jun 24, 1994
Application Number:08/265,438
Claims:1. 1.alpha.,24 dihydroxy vitamin D.sub.4.

2. A pharmaceutical composition, comprising an amount effective to increase serum calcium in a patient suffering Vitamin D deficiency of 1.alpha.,24 dihydroxy vitamin D.sub.4 in combination with a pharmaceutically acceptable vehicle.

3. The pharamaceutical composition of claim 2, wherein said amount is administered orally.

4. 1.alpha.,24-dihydroxyvitamin D.sub.4 produced in accordance with the method comprising incubating 1.alpha.-hydroxyvitamin D.sub.4 with cultured human liver cells to form 1.alpha.,24-dihydroxyvitamin D.sub.4, and isolating and purifying the 1.alpha.,24-dihydroxyvitamin D.sub.4 via high pressure liquid chromatography.
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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
Johnson and Johnson
Chinese Patent Office
Farmers Insurance

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