Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Cantor Fitzgerald
Johnson and Johnson

Generated: June 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,025,346

« Back to Dashboard

Title: 1.alpha.-hydroxy vitamin D.sub.4 and novel intermediates and analogues
Abstract:Disclosed is 1.alpha.,24-dihydroxy vitamin D.sub.4 having the following structure: ##STR1## and pharmaceutical compositions containing said compound. The compound and composition are useful in the treatment of abnormal calcium metabolism. Also Disclosed is a method for the preparation of 1.alpha.,24-dihydroxy vitamin D.sub.4.
Inventor(s): Knutson; Joyce C. (Madison, WI), Bishop; Charles W. (Verona, WI), Moriarty; Robert M. (Oak Park, IL)
Assignee: Bone Care International, Inc. (Madison, WI)
Filing Date:Jun 24, 1994
Application Number:08/265,438
Claims:1. 1.alpha.,24 dihydroxy vitamin D.sub.4.

2. A pharmaceutical composition, comprising an amount effective to increase serum calcium in a patient suffering Vitamin D deficiency of 1.alpha.,24 dihydroxy vitamin D.sub.4 in combination with a pharmaceutically acceptable vehicle.

3. The pharamaceutical composition of claim 2, wherein said amount is administered orally.

4. 1.alpha.,24-dihydroxyvitamin D.sub.4 produced in accordance with the method comprising incubating 1.alpha.-hydroxyvitamin D.sub.4 with cultured human liver cells to form 1.alpha.,24-dihydroxyvitamin D.sub.4, and isolating and purifying the 1.alpha.,24-dihydroxyvitamin D.sub.4 via high pressure liquid chromatography.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Johnson and Johnson
Boehringer Ingelheim

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.