|Title:|| 1.alpha.-hydroxy vitamin D.sub.4 and novel intermediates and analogues|
|Abstract:||Disclosed is 1.alpha.,24-dihydroxy vitamin D.sub.4 having the following structure: ##STR1## and pharmaceutical compositions containing said compound. The compound and composition are useful in the treatment of abnormal calcium metabolism. Also Disclosed is a method for the preparation of 1.alpha.,24-dihydroxy vitamin D.sub.4.|
|Inventor(s):|| Knutson; Joyce C. (Madison, WI), Bishop; Charles W. (Verona, WI), Moriarty; Robert M. (Oak Park, IL) |
|Assignee:|| Bone Care International, Inc. (Madison, WI) |
|Filing Date:||Jun 24, 1994|
|Claims:||1. 1.alpha.,24 dihydroxy vitamin D.sub.4. |
2. A pharmaceutical composition, comprising an amount effective to increase serum calcium in a patient suffering Vitamin D deficiency of 1.alpha.,24 dihydroxy vitamin D.sub.4 in combination with a pharmaceutically acceptable vehicle.
3. The pharamaceutical composition of claim 2, wherein said amount is administered orally.
4. 1.alpha.,24-dihydroxyvitamin D.sub.4 produced in accordance with the method comprising incubating 1.alpha.-hydroxyvitamin D.sub.4 with cultured human liver cells to form 1.alpha.,24-dihydroxyvitamin D.sub.4, and isolating and purifying the 1.alpha.,24-dihydroxyvitamin D.sub.4 via high pressure liquid chromatography.