.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 6,017,521

« Back to Dashboard

Details for Patent: 6,017,521

Title: Use of polycarboxylic acid polymers to treat vaginal infections
Abstract:The present invention relates to the use of a bioadhesive aqueous composition to control the pH of the vagina to alleviate microorganism growth and feminine odor such as presented by bacterial vaginosis. The composition contemplated herein comprises water and an acidic polymer, specifically one wherein 80% of the monomers contain at least one carboxyl group [--COOH] and wherein the polymer is cross-linked so as to be water-swellable, but water-insoluble. The composition of the present invention is additionally a bioadhesive providing for a long-lasting benefit and control of vaginal pH.
Inventor(s): Robinson; Joseph R. (Madison, WI), Bologna; William J. (NY, NY)
Assignee: Columbia Laboratories, Inc. (Aventura, FL)
Filing Date:Oct 16, 1997
Application Number:08/951,419
Claims:1. A method of treating bacterial vaginosis comprising (a) topically contacting the luininal surface of vaginal epithclial cells with an effective pH buffering amount of an aqueous compositions comprising water and an effective amout of a water-swellable, but water-insoluble, cross-linked pH buffering bioadhesive polymer wherein at least 80% of the monomers comprising said polymer contain at least one carboxyl group; and (b) maintaining said contact for a time period sufficient to lower the pH of the vagina to an acidic pH, said composition being free of treating agent.

2. The method according to claim 1 wherein at least 90% of the nmonomers comprising the polymer contain at least one carboxyl group.

3. The method according to claim 1 wherein the aqueous composition further comprises a consistency-ending agent.

4. The method according to claim 1 wherein the polymer comprises monomers at last 90% of which are acrylic acid.

5. The method according to claim 1 wherein the aqueous composition further comprises an adjuvant selected from the group consisting of preservatives, lubricating oils, emulsifying agents, coloring agents, odor-providing agents, and humectants.

6. The method according to claim 1 wherein the polymer is cross-linked with a cross-linking agent added to the polymer at about 0.01 to about 6 weight percent of the polymer.

7. The method according to claim 1 wherein said polymer is polycarbophil.

8. A method of buffering a mammalian vagina to a pH less than about 6.0 comprising (a) contacting the surface of vaginal epithelial cells with an effective pH buffering amount of an aqueous composition comprising water and an effective amounts of a water-swellable, but water-insoluble, pH-buffering bioadhesive cross-linked polymer wherein at least 80% of the monomers comprising said polymer contain at least one carboxyl group; and (b) maintaining said contact for a time period sufficient to lower the pH of the vagina to an acidic pH, said composition being free of treating agent.

9. The method according to claim 8 wherein said polymer is polycarbophil.

10. The method according to claim 8 wherein the polymer comprises monomers, at least 90% of which are acrylic acid.

11. The method according to claim 8 wherein the aqueous composition further comprises an adjuvant selected from the group consisting of preservatives, lubricating oils,emulsifying agents, coloring agents, odor-providing agents, and humectants.

12. The method according to claim 8 wherein the polymer is cross-linked with a cross-linking agent added to the polymer at about 0.01 to about 6 weight percent of the polymer.

13. The method according to claim 8 wherein the aqueous composition further comprises a consistency-enhancing agent.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc