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Details for Patent: 5,993,859

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Details for Patent: 5,993,859

Title: Pharmaceutical agents
Abstract:The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.
Inventor(s): Timko; Robert Joseph (West Chester, PA), Bradway; Randy John (Downingtown, PA), Clements; Arlene (Turnersville, NJ)
Assignee: Zeneca Limited (London, GB)
Filing Date:Jul 13, 1998
Application Number:09/114,225
Claims:1. A process for the preparation of a pharmaceutical composition which comprises, as active ingredient, a physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide substantially free of other physical forms, which physical form has an infra-red spectrum (0.5% in KBr) having sharp peaks at 1690, 1530, 1490, 1420, 1155, 1060, 862 and 550 cm.sup.-1, and polyvinylpyrrolidone, which process comprises mixing said active ingredient with polyvinylpyrrolidone and water, and drying the resultant mixture.
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