Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Federal Trade Commission
Argus Health

Generated: May 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,976,494

« Back to Dashboard

Title: Technetium-99m labeled peptides for imaging
Abstract:This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via Tc-99m binding moieties. In particular, the peptide reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.
Inventor(s): Dean; Richard T. (Bedford, NH), Lister-James; John (Bedford, NH)
Assignee: Diatide, Inc. (Londonderry, NH)
Filing Date:Jun 06, 1995
Application Number:08/469,858
Claims:1. A kit comprising a sealed vial containing:

a) a predetermined quantity of a reagent selected from the group consisting of:

(acetyl-F.sub.D PRPG).sub.2 KGGGCamide;

(GPRVVERHQSA).sub.2 KC.sub.Acm GC.sub.Acm amide; ##STR8## (CC.sub.Acm GC.sub.Acm GGRGDS).sub.3 -TSEA; (GPRPC.sub.Acm GC.sub.Acm Camide).sub.3 -TSEA;

(Pic.SC.sub.Acm SYNRGDSTCamide).sub.3 -TSEA;

(RALVDTLKGGC.sub.Acm GC.sub.Acm Camide).sub.3 -TSEA;

(GRGDFC.sub.Acm GC.sub.Acm Camide).sub.3 -TSEA;

(Pic.GC.sub.Acm RALVDTLKFVTQAETGAKCamide).sub.3 -TSEA; and

(acetyl-SYNRGDTC.sub.Acm GC.sub.Acm Camide).sub.2 -DMAB;


b) a sufficient amount of a reducing agent to label the reagent with technetium-99m.

2. A kit comprising a sealed vial containing a predetermined quantity of a reagent having a formula: ##STR9## and a sufficient amount of a reducing agent to label said reagent with technetium-99m.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Cantor Fitzgerald
US Army
Federal Trade Commission
Johnson and Johnson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.