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Details for Patent: 5,968,500

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Details for Patent: 5,968,500

Title: Tissue moisturizing composition and method
Abstract:A composition and method of moisturizing mammalian membranous tissue is disclosed. The composition utilized in this method includes water, a bioadhesive polymer as the moisturizing agent, and preferably, a consistency-enhancing agent. The bioadhesive is a water-swellable, but water-insoluble, particulate, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether. The consistency-enhancing agent, when present, is a water-soluble or -dispersible anionic or non-ionic polymer. The composition is contacted with the tissue to be moisturized, and that contact is maintained for a time period sufficient to moisturize the contacted area.
Inventor(s): Robinson; Joseph R. (Madison, WI)
Assignee: Columbia Laboratories, Inc. (Aventura, FL)
Filing Date:Oct 15, 1997
Application Number:08/950,835
Claims:1. A method of moisturizing mammalian epithelial cells comprising:

(a) contacting mammalian epithelial cells to be moisturized with an effective moisturizing amount of an aqueous composition, which is free of a treating agent, comprising water and a moisturizing amount of a bioadhesive moisturizing polymer having an adhesive force of at least about 380 dynes per square centimeter, said bioadhesive moisturizing polymer comprising a water-swellable, but water-insoluble, cross-linked caboxy-functional polymer; and

(b) maintaining said contact for a time period sufficient to moisturize said contacted epithelial cells.

2. An epithelial tissue moisturizing composition, which is free of a treating agent, comprising water and a moisturizing amount of a bioadhesive moisturizing polymer having an adhesive force of at least about 380 dynes per square centimeter, said bioadhesive moisturizing polymer comprising particles of a water-swellable, but water-insoluble, cross-linked carboxy-functional polymer in free acid form.

3. An epithelial tissue moisturizing composition, which is free of a treating agent, comprising water and a moisturizing amount of a bioadhesive moisturizing polymer having an adhesive force of at least about 380 dynes per square centimeter, said bioadhesive moisturizing polymer consisting essentially of particles of a water-swellable, but water-insoluble, cross-linked carboxy-finctional polymer consisting essentially of (a) a plurality of repeating units which contain at least one carboxyl functionality in its free acid form, and (b) about 0.01 to about 6 percent cross-linking agent, said percentages being based upon the weights of unpolymerized repeating units and cross-linking agent, respectively.

4. The method according to claim 1 wherein said bioadhesive polymer consists essentially of repeating units essentially all of which contain at least one carboxyl functionality in its free acid form.

5. The method according to claim 4 wherein said bioadhesive polymer contains about 0.01 to about 6 percent cross-linking agent.

6. The method according to claim 5 wherein said cross-linking agent is substantially free from polyalkenyl polyether.

7. The composition according to claim 2 wherein said bioadhesive polymer contains a plurality of repeating units of which essentially all contain at least one carboxyl functionality.

8. The composition according to claim 7 wherein said bioadhesive polymer contains about 0.01 to about 6 percent cross-linking agent.

9. The composition according to claim 8 wherein said cross-linking agent is substantially free from polyalkenyl polyether.

10. The composition according to claim 2 wherein said bioadhesive polymer contains a plurality of repeating units essentially all of which contain at least one carboxyl functionality in its free acid form.

11. The composition according to claim 10 wherein said bioadhesive polymer contains about 0.01 to about 6 percent cross-linking agent.

12. The composition according to claim 11 wherein said cross-linking agent is substantially free from polyalkenyl polyether.
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