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Details for Patent: 5,965,592

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Details for Patent: 5,965,592

Title: Acyl compounds
Abstract:Compounds of the formula ##STR1## and their salts, in which R.sub.1, is a C.sub.1 -C.sub.7 aliphatic hydrocarbon radical; X.sub.1 is --CO; X.sub.2 is a divalent aliphatic hydrocarbon radical which comprises an ethyl group and an alkylene of 2 to 6 carbon atoms; R.sub.2 is hydroxy, carboxy or alkoxycarbonyl in which alkoxy is from 1 to 7 carbon atoms; X.sub.3 is a divalent aliphatic hydrocarbon; R.sub.3 is carboxyl or 5-tetrazolyl; and the rings A and B independently of one another are otherwise unsubstituted; can be prepared in a known manner and may be used as active ingredients for medicaments.
Inventor(s): Buhlmayer; Peter (Arlesheim, CH), Ostermayer; Franz (Riehen, CH), Schmidlin; Tibur (Basel, CH)
Assignee: Novartis Corporation (Summit, NJ)
Filing Date:Jul 29, 1998
Application Number:09/124,520
Claims:1. A compound of the formula: ##STR11## in which R1 is alkyl of 1 to 7 carbon atoms;

R2 is hydroxy, carboxy, or alkoxycarbonyl in which alkoxy having from 1 to 7 carbon atoms;

R3 is carboxy or 1H-tetrazol-5-yl; and

X.sub.4 and X.sub.5 taken together are alkylene of 2 to 6 carbon atoms, or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 in which

R1 is CH.sub.3 CH.sub.2 CH.sub.2 --, CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 --, or CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --;

R2 is --COOH, --COOCH.sub.3, or --COOCH.sub.2 CH.sub.3 ; and

X.sub.4 and X.sub.5 taken together are --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --.

3. The compound according to claim 1 in which R1 is CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 -- and X.sub.4 and X.sub.5 taken together are --(CH.sub.2).sub.4 --.

4. The compound according to claim 1 in which R1 is CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 -- and X.sub.4 and X.sub.5 taken together are --(CH.sub.2).sub.5 --.

5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 1.

6. A method of treating hypertension in a warm blooded animal comprising administering to an animal in need of such treatment an effective amount of a compound according to claim 1.
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