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Details for Patent: 5,955,490

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Details for Patent: 5,955,490

Title: Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
Abstract:Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.
Inventor(s): Kennedy; James C. (Kingston, CA), Pottier; Roy H. (Kingston, CA), Reid; Robert L. (Kingston, CA), Sac-Morales; Arnold (Kingston, CA), Tomalty; Lewis L. (Inverary, CA)
Assignee: Queen's University at Kingston (Kingston, CA)
Filing Date:Jun 05, 1995
Application Number:08/465,242
Claims:1. A method for treating acne, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to a patient in need of such treatment, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.

2. A method according to claim 1, wherein said acne is associated with the presence of a Propinobacterium.

3. A method according to claim 1, wherein said precursor is 5-aminolevulinic acid.

4. A method for treating a patient suffering from a disorder associated with a Propinobacterium, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to said patient, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.

5. A method according to claim 4, wherein said precursor is 5-aminolevulinic acid.

6. A method for treating malaria, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to a patient in need of such treatment, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.

7. A method according to claim 6, wherein said malaria is associated with the presence of a malarial parasite.

8. A method according to claim 7, wherein said parasite is selected from the group consisting of Plasmodium falciparum, Plasmodium ovale, Plasmodium malaria, and Plasmodium vivax.

9. A method for treating a patient suffering from a disorder associated with the presence of a parasite selected from the group consisting of Plasmodium falciparum, Plasmodium ovale, Plasmodium malaria, and Plasmodium vivax, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to said patient, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.

10. A method according to claim 6, wherein said precursor is 5-aminolevulinic acid.

11. A method for treating a skin lesion that is associated with the presence of a bacterium, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to a patient in need of such treatment, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.

12. A method according to claim 11, wherein said precursor is 5-aminolevulinic acid.
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