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Generated: December 17, 2017

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Title: Polymeric compositions useful as controlled release implants
Abstract:The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.
Inventor(s): Dunn; Richard L. (Fort Collins, CO), Tipton; Arthur J. (Fort Collins, CO)
Assignee: Atrix Laboratories, Inc. (Fort Collins, CO)
Filing Date:Aug 08, 1997
Application Number:08/908,263
Claims:1. A composition suitable for in situ formation of an implant in an animal, comprising:

(a) a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in aqueous or body fluids;

(b) a biocompatible organic solvent which solubilizes the thermoplastic polymer, is miscible to dispersible in aqueous or body fluids, and is capable of dissipating from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms the implant; and

(c) a biologically active agent capable of enhancing bone growth.

2. The composition of claim 1, further comprising a release rate modifying agent.

3. The composition of claim 1 wherein the biologically active material is demineralized bone matrix.

4. The composition of claim 1 wherein the biological active material is bone morphogenic protein.
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