Anticipate generic drug launch
Find generic entry opportunities
Manage your formulary budget
Drug patents …
… from Kazakhstan to Kalamazoo
Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Proactively manage your pharmacy inventory
Flat-rate pricing for predictable budgeting
Short-term plans for project- or client-based billing
|Title:||Polymeric compositions useful as controlled release implants|
|Abstract:||The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.|
|Inventor(s):||Dunn; Richard L. (Fort Collins, CO), Tipton; Arthur J. (Fort Collins, CO)|
|Assignee:||Atrix Laboratories, Inc. (Fort Collins, CO)|
|Filing Date:||Aug 08, 1997|
|Claims:||1. A composition suitable for in situ formation of an implant in an animal, comprising: |
(a) a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in aqueous or body fluids;
(b) a biocompatible organic solvent which solubilizes the thermoplastic polymer, is miscible to dispersible in aqueous or body fluids, and is capable of dissipating from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms the implant; and
(c) a biologically active agent capable of enhancing bone growth.
2. The composition of claim 1, further comprising a release rate modifying agent.
3. The composition of claim 1 wherein the biologically active material is demineralized bone matrix.
4. The composition of claim 1 wherein the biological active material is bone morphogenic protein.