Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim

Generated: May 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,945,115

« Back to Dashboard

Title: Polymeric compositions useful as controlled release implants
Abstract:The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.
Inventor(s): Dunn; Richard L. (Fort Collins, CO), Tipton; Arthur J. (Fort Collins, CO)
Assignee: Atrix Laboratories, Inc. (Fort Collins, CO)
Filing Date:Aug 08, 1997
Application Number:08/908,263
Claims:1. A composition suitable for in situ formation of an implant in an animal, comprising:

(a) a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in aqueous or body fluids;

(b) a biocompatible organic solvent which solubilizes the thermoplastic polymer, is miscible to dispersible in aqueous or body fluids, and is capable of dissipating from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms the implant; and

(c) a biologically active agent capable of enhancing bone growth.

2. The composition of claim 1, further comprising a release rate modifying agent.

3. The composition of claim 1 wherein the biologically active material is demineralized bone matrix.

4. The composition of claim 1 wherein the biological active material is bone morphogenic protein.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Farmers Insurance
Chinese Patent Office

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.