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Details for Patent: 5,932,616

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Details for Patent: 5,932,616

Title: Potent inducers of terminal differentiation and methods of use thereof
Abstract:The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
Inventor(s): Breslow; Ronald (Englewood, NJ), Marks; Paul A. (Bridgewater, CT), Rifkind; Richard A. (New York, NY), Jursic; Branko (New Orleans, LA)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY) The Trustees of Columbia Univerisity in the City of New York (New York, NY)
Filing Date:Apr 04, 1994
Application Number:08/222,685
Claims:1. A compound having the structure: ##STR108## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group; R is a hydrogen atom, a hydroxyl group, a substituted or unsubstituted alkyl, aryl, alkyloxy, or aryloxy group; and each of m and n are independently the same as or different from each other and are each an integer from 0 to 8.

2. A compound of claim 1, wherein each of X, Y, and R is a hydroxyl group and each of m and n is 5.

3. A compound having the structure: ##STR109## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group; each of R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted alkyl, aryl, alkyloxy, or aryloxy group; and each of m, n, and o are independently the same as or different from each other and are each an integer from 0 to 8.

4. A compound of claim 3, wherein each of X and Y is a hydroxyl group and each of R.sub.1 and R.sub.2 is a methyl group.

5. A compound of claim 4, wherein each of n and o is 6, and m is 2.

6. A compound having the structure: ##STR110## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group; each of R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted alkyl, aryl, alkyloxy, or aryloxy group; and each of m and n are independently the same as or different from each other and are each an integer from 0 to 8.

7. A compound having the structure: ##STR111## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group; and each of m and n are independently the same as or different from each other and are each an integer from 0 to 8.

8. A compound of claim 7, wherein each of X and Y is a hydroxyl group and each of m and n is 5.

9. A compound having the structure: ##STR112## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group; each of R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted alkyl, aryl, alkyloxy, or aryloxy group; and each of m and n are independently the same as or different from each other and are each an integer from 0 to 8.

10. A compound having the structure: ##STR113## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group; and n is an integer from 1 to 8 provided that X and Y are not both dialkylamino.

11. A compound having the structure: ##STR114## wherein each of X and Y are independently the same as or different from each other and are a hydroxyl, amino, or hydroxylamino group, a substituted or unsubstituted alkyloxy, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group, provided that when X is a hydroxy or alkyloxy, Y cannot be a hydroxy or alkyloxy; R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydrogen atom, a substituted or unsubstituted alkyl, aryl, alkyloxy, aryloxy, carbonylhydroxylamino, or fluoro group, provided that R.sub.1 and R.sub.2 are not both hydrogen atoms; and m and n are independently the same or different from each other and are each an integer from 1 to 8.

12. A compound of claim 11, wherein each of X and Y is a hydroxylamino group; R.sub.1 is a methyl group; R.sub.2 is a hydrogen atom; and each of m and n is 2.

13. A compound of claim 11, wherein each of X and Y is a hydroxylamino group; R.sub.1 is a carbonylhydroxylamino group; R.sub.2 is a hydrogen atom; and each of m and n is 5.

14. A compound of claim 11, wherein each of X and Y is a hydroxylamino group; each of R.sub.1 and R.sub.2 is a fluoro group; and each of m and n is 2.

15. A compound having the structure: ##STR115## wherein R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydroxyl, alkyloxy, amino, hydroxylamino, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group R.sub.1 and R.sub.2 are not both hisdroxyl or arylamino.

16. A compound of claim 15, wherein R.sub.1 is a phenylamino group and R.sub.2 is a hydroxylamino group.

17. A compound having the structure: ##STR116## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydroxyl, alkyloxy, amino, hydroxylamino, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group provided that R.sub.1 and R.sub.2 are not both hydroxylamino.

18. A compound of claim 17, wherein R.sub.1 is phenylamino group and R.sub.2 is hydroxylamino group.

19. A compoun d having the structure: ##STR117## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other and are a hydroxyl, alkyloxy, amino, hydroxylamino, alkylamino, dialkylamino, arylamino, alkylarylamino, alkyloxyamino, aryloxyamino, alkyloxyalkylamino, or aryloxyalkylamino group provided that R.sub.1 and R.sub.2 are not both hydroxylamino.

20. A compound of claim 19, wherein R.sub.1 is a hydroxylamino group.

21. A compound of claim 19, wherein R.sub.2 is a hydroxylamino group.

22. A compound having the structure: ##STR118## wherein R is a phenylamino group substituted with a cyano, methylcyano, nitro, carboxyl, aminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, trifluoromethyl, hydroxylaminocarbonyl, N-hydroxylaminocarbonyl, methoxycarbonyl, chloro, fluoro, methyl, methoxy, 2,3-difluoro, 2,4-difluoro, 2,5-difluoro, 2,6-difuloro, 3,5-difluoro, 2,3,6-trifluoro, 2,4,6-trifluoro, 1,2,3-trifluoro, 3,4,5-trifluoro, 2,3,4,5-tetrafluoro, or 2,3,4,5,6-pentafluoro group; and n is an integer from 4 to 8.

23. A method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable conditions with an effective amount of the compound of claim 1, 6, 7, 9, 10, 11, 15, 17, 19, 22 or 3 effective to selectively induce terminal differentiation.

24. A method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an effective amount of the compound of claim 1, 6, 7, 9, 10, 11, 15, 17, 19, 22 or 3 effective to selectively induce terminal differentiation of such neoplastic cells and thereby inhibit their proliferation.

25. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound of claim 1, 6, 7, 9, 10, 11, 15, 17, 19, 22 or 3.

26. A pharmaceutical composition of claim 25, wherein the effective amount is an amount effective to selectively induce terminal differentiation of suitable neoplastic cells and less than an amount which causes toxicity in a patient.

27. A pharmaceutical composition of claim 25 in combination with an antitumor agent.
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