Details for Patent: 5,922,338

Title:	Polyol esters, their preparation and use in depot forms of pharmacologically active agents
Abstract:	This invention provides a polyester of a polyol, said polyol containing at least 3 hydroxyl groups and having a molecular weight of up to 20,000 at least 1 hydroxyl group in said polyol being in the form of an ester, with a poly- or co-poly-lactic acid residue, each having a molecular weight of at least from 5,000. These are useful for parenteral depot formulations.
Inventor(s):	Brich; Zdenek (Binningen, CH), Kissel; Thomas (Ehrenkirchen, DE)
Assignee:	Novartis AG (Basel, CH)
Filing Date:	Jun 06, 1995
Application Number:	08/471,304
Claims:	1. A branched polyglycolide lactide ester of glucose, having a molecular weight of from 20,000 to 200,000. 2. The ester of glucose of claim 1 having a molecular weight of 20,000 to 80,000. 3. A formulation comprising a matrix of said ester of glucose of claim 1 and a therapeutically effective amount of a pharmacologically active agent. 4. A formulation of claim 3 wherein said active agent is selected from the group consisting of bromocriptine, ketotifen and co-dergocrine. 5. A formulation of claim 3 wherein said formulation is in implant form. 6. A formulation of claim 3 wherein said formulation is in microcapsule form.