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|Abstract:||A method of crosslinking a crosslinkable protein or carbohydrate substrate to form a crosslinked substrate in which the crosslinking groups are biodegradable. The crosslinking groups may comprise methylene diacrylate and the substrate can be galactose.|
|Inventor(s):||Klaveness; Jo (Oslo, NO), Rongved; P.ang.l (Nesoddtangen, NO), Strande; Per (Oslo, NO)|
|Assignee:||Nycomed Imaging AS (Oslo, NO)|
|Filing Date:||Jun 02, 1995|
|Claims:||1. A method of crosslinking a crosslinkable protein or carbohydrate substrate to form a crosslinked substrate in which the crosslinking groups are biodegradable, said method comprising reacting said crosslinkable substrate with a crosslinking agent of formula (IIIa) ##STR13## wherein Q is selected from the group consisting of halogen atoms, alkanesulphonyloxy groups, arenesulphonyloxy groups and groups of formula --O.CO.(O).sub.n.R.sup.9.B; |
m and n may be the same or different and are each selected from the group consisting of zero and 1;
R.sup.1 and R.sup.2 may be the same or different and are each selected from the group consisting of hydrogen atoms, aliphatic, cycloalkyl, araliphatic, aryl and heterocyclic groups, groups of formula --O.CO.(O).sub.m.R.sup.8.A and groups of formula --O.CO.(O).sub.n.R.sup.9.B, or R.sup.1 and R.sup.2 together form an alkylene, alkenylene, alkylidene or alkenylidene group;
R.sup.8 and any group R.sup.9 may be the same or different and are each selected from the group consisting of alkylene groups; alkenylene groups; phenyleneethynylmethylene; cycloalkylene groups; arylene groups; C.sub.1-6 alkyl substituted arylene groups; aralkylene groups; C.sub.1-6 alkyl substituted aralkylene groups; heterocyclic groups; any of the foregoing substituted by one or more of oxo, thio, hydroxyl, etherified hydroxyl, esterified hydroxyl, etherified thiol, N--(C.sub.1-6 alkyl) amino, N--(C.sub.1-6 acyl) amino, N--(C.sub.1-6 acyl) --N--(C.sub.1-6 alkyl) amino, carbamoyl, N--(C.sub.1-6 alkyl) carbamoyl and halogen; and any of the foregoing interrupted by oxygen atoms;
and A and any group B may be the same or different and each represents a reactive functional grouping selected from the group consisting of a halogen atom, an aryl halide group, an alkanesulphonyloxy group, an arenesulphonyloxy group, an .alpha.-halomethyl carbonyl group, a carboxyl group, an anhydride group, an optionally sulphonated succinimidyloxy group, a hydroxyl group, a mercapto group, an alkene group, an .alpha., .beta.-alkene ester group, an .alpha., .beta.-alkene amide group, an .alpha., .beta.-alkene ketone group, a conjugated diyne group, a conjugated enyne group, an epoxy group, an amino group, a diazo group, an imidoester group, an alkyl halide group, an aralkyl halide group, a nitroaryl halide group, an aryl azide group, a diazo group, a diazirine group, a formyl group or the dimethyl acetal thereof, an acetyl group, an isocyanate group, an isothiocyanate group, a semicarbazide group, a thiosemicarbazide group, a carboxy (nitro) phenol group, an alkanoyl azide group, a hydrazine group, a haloformate group, an optionally sulphonated maleimide group, a nitrosourea group, an s-triazine group, an aziridine group and a pyridyl disulphide group;
or at least one of A.R.sup.8 -- and any group --R.sup.9.B represents an optionally substituted vinyl group.
2. The method of claim 1 wherein the crosslinking agent is a compound of formula (IIIa) in which R.sup.1 and R.sup.2 are each selected from the group consisting of hydrogen atoms and C.sub.1-4 alkyl groups.
3. The method of claim 1 wherein the crosslinking agent is a compound of formula (IIIa) in which R.sup.8 and any group R.sup.9 are selected from the group consisting of C.sub.1-30 alkylene; C.sub.1-30 alkylene interrupted by one or more oxy, carbonyloxy or oxycarbonyl groups; phenylene; phenyleneoxymethylene and phenyleneethynylmethylene.
4. The method of claim 1 wherein the crosslinking agent is methylene bis(16-hydroxyhexadecanoate).
5. The method of claim 1 wherein the crosslinkable substrate is an ultrasound contrast agent.
6. The method of claim 1 wherein the cross-linking agent is methylene diacrylate.
7. The method of claim 1 wherein the cross-linkable substrate is galactose.
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